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Pyruvate for Weight Control

Also indexed as:Pyruvic Acid
Pyruvate
Pyruvate: Main Image

How Much Is Usually Taken by Dieters?

Pyruvate, a compound that occurs naturally in the body, might aid weight-loss efforts.1 A controlled trial found that pyruvate supplements (22 to 44 grams per day) enhanced weight loss and resulted in a greater reduction of body fat in overweight adults consuming a low-fat diet.2 Three controlled trials combining 6 to 10 grams per day of pyruvate with an exercise program reported greater effects on weight loss and body fat than that seen with a placebo plus the exercise program.3, 4, 5 Animal studies suggest that pyruvate supplementation leads to weight loss by increasing the resting metabolic rate.6

Side Effects

High intakes of pyruvate can trigger gastrointestinal upset, such as gas, bloating, and diarrhea. One preliminary study in exercising women found 10 grams per day of pyruvate reduced blood levels of HDL (the "good" cholesterol) after one month.7

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

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The information presented in Aisle7 is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires June 2015.