{"id":33468,"date":"2024-04-18T21:42:25","date_gmt":"2024-04-19T01:42:25","guid":{"rendered":"https:\/\/whatsgood.vitaminshoppe.com\/?p=33468"},"modified":"2024-04-19T09:34:13","modified_gmt":"2024-04-19T13:34:13","slug":"oral-vs-injectable-semaglutide","status":"publish","type":"post","link":"https:\/\/www.vitaminshoppe.com\/blog\/oral-vs-injectable-semaglutide\/","title":{"rendered":"Oral vs. Injectable Semaglutide: What\u2019s Better Suited For You?"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Chances are, you\u2019ve heard quite a bit about semaglutide, the drug branded as Ozempic\u00ae, Wegovy\u00ae, and Rybelsus\u00ae. These medications, which are commonly prescribed for managing type 2 diabetes and obesity, have been the talk of the town recently due in part to celebrity testimonials; however, semaglutide has been <a href=\"https:\/\/www.pewresearch.org\/short-read\/2024\/03\/21\/as-obesity-rates-rise-in-the-us-and-worldwide-new-weight-loss-drugs-surge-in-popularity\/\">soaring in popularity over the past seven years<\/a>.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Semaglutide mimics the action of a naturally occurring hormone we produce in the gut called glucagon-like peptide-1 (GLP-1), explains Dr. Suzanne Ben-Kane, M.D., M.B.A., M.P.H., an internal medicine specialist in Sarasota, Florida. \u201cThe function of GLP-1 is to send signals from the stomach to the brain so we stop eating when the stomach is full, as well as to regulate our blood sugar levels,\u201d she says. \u201cWhen the body can no longer sense the GLP-1 hormone, such as the case with someone who is obese, a lack of appetite regulation causes you to overeat.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Semaglutide was first introduced in 2017 as an injectable medication (Ozempic\u00ae) to help lower blood sugar in people with type 2 diabetes. However, doctors soon realized that patients on the drug lost an average of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9807016\/#:~:text=48%2C49%20At%20the%20end,compared%20with%202.6%25%20for%20placebo.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">15 percent<\/span><\/a><span style=\"font-weight: 400;\"> of their weight in a year, sparking intense interest in its benefits for weight management. Two years later, in 2019, oral semaglutide (Rybelsus\u00ae) was introduced. In 2021, the FDA gave an injectable semaglutide (Wegovy\u00ae) approval for the treatment of obesity.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Both oral and injectable semaglutide are commonly prescribed today. If you&#8217;re considering medical weight loss with a semaglutide, it&#8217;s important to understand the available options. Here, experts break down how each works, as well as their pros and cons.\u00a0<\/span><\/p>\n<ul>\n<li><em style=\"font-family: 'Josefin Sans', Arial, sans-serif; font-size: 0.875rem; font-weight: bold; text-transform: uppercase;\"><strong>ABOUT OUR EXPERTs: <\/strong><\/em><em><em><em><span style=\"font-weight: 400;\">Dr. Suzanne Ben-Kane, M.D., M.B.A., M.P.H., is an internal medicine specialist in Sarasota, Florida. Dr. <a href=\"https:\/\/weightmedicinemd.com\/\" target=\"_blank\" rel=\"noopener\">Meghan Garcia-Webb<\/a>, M.D., is a physician triple-board-certified in internal medicine, lifestyle medicine, and obesity medicine. Mohit Joshipura, M.D., a board-certified internal medicine physician who specializes in weight management, is a member of the <a href=\"https:\/\/www.vitaminshoppe.com\/blog\/whole-health-rx-medical-advisory-council\/\">Whole Health Rx Medical Advisory Council<\/a>.<\/span><\/em><\/em><\/em><\/li>\n<\/ul>\n<h2><strong>Oral Semaglutide<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">Oral semaglutide, which is sold under the brand name Rybelsus<\/span><span style=\"font-weight: 400;\">\u00ae<\/span><span style=\"font-weight: 400;\">, is currently only <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">FDA-approved for diabetes treatment<\/span><\/a><span style=\"font-weight: 400;\">, though it is sometimes prescribed <a href=\"https:\/\/www.fda.gov\/patients\/learn-about-expanded-access-and-other-treatment-options\/understanding-unapproved-use-approved-drugs-label\">off-label<\/a> for weight loss. (There is no oral form of semaglutide currently approved for weight management.)\u00a0<\/span><\/p>\n<h3><strong>How does it work in the body?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Both oral and injectable semaglutide mimic the GLP-1 hormone in the small intestine that slows the movement of food through the stomach, explains Dr. <\/span><a href=\"https:\/\/weightmedicinemd.com\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Meghan Garcia-Webb<\/span><\/a><span style=\"font-weight: 400;\">, M.D., a physician triple-board-certified in internal medicine, lifestyle medicine, and obesity medicine. A feeling of fullness is created by slowing down the emptying of food from your stomach.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, \u201cwhen GLP-1 is released by the intestines, it plays a crucial role in regulating blood sugar levels by stimulating secretion from the pancreas,\u201d she says. \u201cSemaglutide activates these receptors, which increases insulin release in response to elevated blood glucose levels, thereby lowering blood sugar levels and reducing the risk of high blood glucose for those with diabetes.\u201d<\/span><\/p>\n<h3><strong>How is it administered?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Oral semaglutide is a <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6969659\/#:~:text=It%20is%20recommended%20that%20oral,the%20effect%20of%20the%20medication.\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">pill that is taken once daily<\/span><\/a><span style=\"font-weight: 400;\">, ideally with water and 30 minutes prior to the first food or other beverage of the day.\u00a0<\/span><\/p>\n<h3><strong>What are the side effects?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">The most common side effects of oral semaglutide are gastrointestinal symptoms such as nausea, vomiting, blurred vision, and constipation, explains Ben-Kane. \u201cA less common side effect is acute pancreatitis, which is an inflammation of the pancreas,\u201d she says. \u201cIt causes very severe stomach pain.\u201d Other <\/span><a href=\"https:\/\/www.novo-pi.com\/rybelsus.pdf#guide\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">more serious, but less common, side effects<\/span><\/a><span style=\"font-weight: 400;\"> include acute kidney failure, gallbladder disease, diabetic retinopathy, and hypoglycemia.\u00a0<\/span><\/p>\n<p><strong>Read More: <a href=\"https:\/\/www.vitaminshoppe.com\/blog\/glp-1-nutritional-gaps\/\" target=\"_blank\" rel=\"noopener\">How To Fill Nutritional Gaps If You&#8217;re On A GLP-1 Weight Loss Drug<\/a><\/strong><\/p>\n<h3><strong>Benefits of oral semaglutide\u00a0<\/strong><\/h3>\n<p><a href=\"https:\/\/go.skimresources.com\/?id=41977X1601025&amp;isjs=1&amp;jv=15.5.0&amp;sref=https%3A%2F%2Fwww.healthline.com%2Fhealth%2Fweight-loss%2Fsemaglutide-oral-vs-injection%23oral-vs-injectable&amp;url=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs13300-021-01034-w&amp;xs=1&amp;xtz=240&amp;xuuid=6dd5ce5a973f4049aee6280f73ad52a7&amp;xjsf=other_click__contextmenu%20%5B2%5D\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Recent research<\/span><\/a><span style=\"font-weight: 400;\"> suggests that oral semaglutide is effective for reducing A1C and promoting weight loss in people with type 2 diabetes. Oral semaglutide is also a good option for those who do not want to inject themselves and do not mind a daily medication, according to board-certified internal medicine physician and member of the <a href=\"https:\/\/www.vitaminshoppe.com\/blog\/whole-health-rx-medical-advisory-council\/\">Whole Health Rx Medical Advisory Council<\/a> Mohit Joshipura, M.D., who specializes in weight management.\u00a0<\/span><\/p>\n<h3><strong>Drawbacks of oral semaglutide\u00a0<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Unfortunately, it\u2019s more common to experience gastrointestinal upset\u2014think nausea, vomiting, diarrhea, and constipation\u2014when taking oral semaglutide, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9631444\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">research<\/span><\/a><span style=\"font-weight: 400;\"> suggests. For most people, these side effects tend to dissipate after the first few weeks of taking the drug; however, they can linger longer for some patients.\u00a0<\/span><\/p>\n<h2><strong>Injectable Semaglutide<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">Injectable semaglutide is currently available in <\/span><a href=\"https:\/\/www.fda.gov\/drugs\/postmarket-drug-safety-information-patients-and-providers\/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">two FDA-approved options<\/span><\/a><span style=\"font-weight: 400;\">: Ozempic, which is approved for type 2 diabetes, and Wegovy, which is approved for weight management.\u00a0<\/span><\/p>\n<h3><strong>How does it work in the body?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Injectable semaglutide, just like oral semaglutide, mimics the action of the GLP-1 hormone. It works by reducing cravings for food and alcohol and by slowing down the emptying of food from your stomach, which contributes to satiety. It also increases the release of insulin into your body, which helps lower blood sugar.<\/span><\/p>\n<h3><strong>How is it administered?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Injectable semaglutide is administered via an injection into subcutaneous fat tissue (think hips, buttocks, thighs, or belly) once per week.<\/span><\/p>\n<h3><strong>What are the side effects?<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Because injectable semaglutide is administered with a needle, you may <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7887535\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">experience bruising at the site of the injection<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><span style=\"font-weight: 400;\">Otherwise, as with oral semaglutide, the most common side effects of the injectable version are gastrointestinal symptoms such as nausea, vomiting, constipation, burping, and heartburn, according to Ben-Kane. <a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2810542\" target=\"_blank\" rel=\"noopener\">Pancreatitis<\/a> is another potential adverse effect.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other serious but uncommon potential side effects include <\/span><a href=\"https:\/\/www.ozempic.com\/important-safety-information.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">certain cancers<\/span><\/a><span style=\"font-weight: 400;\">, namely cancer of the thyroid gland.\u00a0<\/span><\/p>\n<h3><strong>Benefits of injectable semaglutide\u00a0<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Perhaps the biggest day-to-day benefit of opting for the injectable form of semaglutide is that you only have to inject yourself once a week as opposed to remembering to take an oral medication once daily, suggests Garcia-Webb.\u00a0<\/span><\/p>\n<p><strong>Read More: <a href=\"https:\/\/www.vitaminshoppe.com\/blog\/fiber-supplements-2\/\" target=\"_blank\" rel=\"noopener\">How To Make Supplementing With Fiber More Enjoyable<\/a><\/strong><\/p>\n<p><span style=\"font-weight: 400;\">You may also experience fewer gastrointestinal side effects when taking the injectable semaglutide, a trend Garcia-Webb has noticed in her own practice. This may be due to the fact that the medication doesn\u2019t have to travel through your digestive tract.\u00a0\u00a0<\/span><\/p>\n<h3><strong>Drawbacks of injectable semaglutide\u00a0<\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">The biggest drawback of injectable semaglutide is that you have to inject yourself with a needle once a week, which may be difficult for those who are afraid of needles or sensitive to pain.\u00a0<\/span><\/p>\n<h2><strong>Which is right for you?<\/strong><\/h2>\n<p><span style=\"font-weight: 400;\">If you\u2019re interested in either oral or injectable semaglutide medication, a good place to start is learning whether or not you&#8217;re a reasonable candidate for prescription. You can take a short questionnaire about your medical history, stats, and goals at <a href=\"http:\/\/www.vitaminshoppe.com\/glp1weightloss\">Whole Health Rx<\/a> to find out, and ultimately be paired with an experienced practitioner if you qualify.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cIt\u2019s very important to find a physician who is familiar with these medications and will be able to monitor you, either virtually or in-person, as semaglutide is titrated up over time and there are often side effects that need to be addressed,\u201d says Garcia-Webb.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Otherwise, factors such as cost and medication availability might influence which option you go with, says Joshipura.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Should all those factors align, your personal preferences may also drive the decision. If you don\u2019t mind taking a daily pill or can\u2019t stomach the thought of a weekly needle, the oral route may be best, suggests Ben-Kane. Otherwise, you might consider the simplicity of a once-weekly injection and the potential for fewer side effects.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chances are, you\u2019ve heard quite a bit about semaglutide, the drug branded as Ozempic\u00ae, Wegovy\u00ae, and Rybelsus\u00ae. These medications, which are commonly prescribed for managing type 2 diabetes and obesity, have been the talk of the town recently due in part to celebrity testimonials; however, semaglutide has been soaring in popularity over the past seven<a class=\"more-link\" href=\"https:\/\/www.vitaminshoppe.com\/blog\/oral-vs-injectable-semaglutide\/\">Read More <span class=\"screen-reader-text\">Oral vs. Injectable Semaglutide: What\u2019s Better Suited For You?<\/span><\/a><\/p>\n","protected":false},"author":78,"featured_media":33471,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1470],"tags":[],"class_list":["post-33468","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-whole-health-rx"],"jetpack_publicize_connections":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Oral vs. Injectable Semaglutide: What\u2019s Better Suited For You? | What\u2019s Good blog<\/title>\n<meta name=\"description\" content=\"You&#039;ve probably heard a lot about semaglutide prescription drugs. 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