Methyl Folate (6S) 5-methyl tetrahydrofolate or 5-MTHF) is the most biologically active form of folic acid.

QUATREFOLIC is the 4th generation development in folate delivery. With certain inherited errors in metabolism and under a variety of physiologic stresses, the transformation of Folic Acid into the active form of folate either does not properly take place or is inadequate. Unlike folic acid, this form of folate can cross the blood-brain barrier. Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division. Folate supplementation duting pregnancy has been shown to reduce the risk of neutral tube birth defects.

• Supports cardiovascular and brain health
• Helps maintain healthy homocysteine levels
• Non-GMO and gluten-free

Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This formula features 1,700mcg of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

Frequently Asked Questions

What is homocysteine?

Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

What does “bioavailable” mean?

When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

• Provides prenatal support
• Supports cardiovascular health
• Free of gluten, dairy, soy, and nuts

Folic Acid—or folate—is a B-vitamin found in leafy green veggies, nuts, beans, and fortified grains. Folic acid is essential for cell division and the creation of DNA and other genetic material, making it a must-have vitamin for moms-to-be.

If your diet doesn't include a lot of leafy greens, beans, or nuts, supplementing with The Vitamin Shoppe^® brand Folic Acid is a great way to support a healthy pregnancy and happy heart.

• Supports energy production and the nervous system
• Contains 680mcg of folate and 1,000mcg of vitamin B12 per serving
• Free of gluten, dairy, soy, nuts, and artificial colors or sweeteners
• Raspberry flavor

It's hard to be your best when you're feeling low on energy and mentally fatigued. But don't hit the snooze button on your goals just yet—vitamin B12 and folic acid can help! These essential B vitamins aid in energy production and normal cell division to support the mental and physical energy you need to power through your day.

Did we mention that it's also delicious? The Vitamin Shoppe^® brand B12 with Folic Acid liquid boasts a tasty Raspberry flavor that's free of artificial colors and sweeteners.