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Primal Defense ULTRA – Ultimate Probiotic Formula – 15 Billion CFU (90 Vegetarian Capsules)

Primal Defense ULTRA – Ultimate Probiotic Formula – 15 Billion CFU (90 Vegetarian Capsules)

$49.99
($0.55/serving)

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Primal Defense ULTRA – Ultimate Probiotic Formula – 15 Billion CFU (90 Vegetarian Capsules)

Rated 4.7 out of 5
101 Reviews21 Questions434 Answers
Gluten FreeVegetarianDairy Free
$49.99
($0.55/serving)

BOGO

BUY ONE, GET ONE 50% OFF

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Product Info

About This Product

  • Primal Defense Ultra probiotic supplement contains Lactobaccilus acidophilus, Bifidobacteria, and other strains to maximize the benefits of a healthy diet, boost nutrient absorption, relieve constipation and support digestive health
  • The only shelf stable daily probiotic powder formula containing a unique whole food blend with Homeostatic Soil Organisms (HSO)
  • This dietary supplement has 15 billion CFU and 13 hardy beneficial strains for immune system health
  • This bifidobacterium probiotic is whole food, gluten free, vegetarian probiotics supplement for a balanced, health internal environment
  • These probiotics for constipation promote regular, healthy and comfortable bowel movements

It combines the benefits of 15 billion CFU and 13 robust strains, including the renowned lactobacillus acidophilus. The inclusion of SBO probiotics, such as Homeostatic Soil Organisms. Designed to fit into your regimen of supplements for women and men, it acts as probiotics for men and women that promote digestive health by supporting a balanced internal environment.† By supporting regular digestive function and immune resilience, Primal Defense Ultra is a great choice for maintaining your body's natural defenses.† Contains Bacillus subtilis to support healthy lactic acid bacteria (Bifidobacterium and/or Lactobacillus) count and healthy pH levels in the gut. The Saccharomyces boulardii in Primal Defense Ultra nourishes intestinal mucosa cells to support the normal barrier function of the intestinal epithelium, the front line for the body's defense system.†

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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Directions

Adults begin with 1 capsule per day with 8oz. of water or juice and gradually increase to 1 capsule 3 times per day. Best taken on an empty stomach.

Warning

As with any dietary supplement consult your healthcare practitioner before using this product, especially if you are pregnant, nursing or under medical supervision. Warning: if you are currently undergoing HIV treatment, chemotherapy, or allograft therapy, do not use before consulting your physician. Do not use if safety seal is broken or missing. Store in a cool dry place. These statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Supplement Facts

Serving Size: 1 Capsule
Number of Servings: 90 Servings
Amount Per Serving
% Daily Value
IRON FROM IONIC PLANT BASED MINERALS   
10%
HSO PROBIOTIC BLEND  - (5 BILLION CFU)
N/A*
SACCHAROMYCES BOULARDII   
N/A*
BARLEY GRASS   
N/A*
OAT GRASS   
N/A*
LACTOBACILLUS PLANTARUM   
N/A*
BACILLUS SUBTILIS   
N/A*
Lactobacillus Paracasei   
N/A*
Bifidobacterium Longum   
N/A*
Bifidobacterium Bifidum   
N/A*
BIFIDOBACTERIUM BREVE   
N/A*
Bifidobacterium Lactis   
N/A*
Lactobacillus Acidophilus   
N/A*
LACTOBACILLUS CASEI   
N/A*
Lactobacillus Rhamnosus   
N/A*
Lactobacillus Salivarius   
N/A*
LACTOBACILLUS BREVIS   
N/A*
IONIC PLANT BASED MINERALS   
N/A*

Other Ingredients:

Vegetable cellulose (capsule), organic rice (hull)

Specifications

Brand:
Garden of Life
Form:
Capsules
Strength:
15 BILL
Serving Size:
1 Capsule
Number of Servings:
90 Servings
Price per Serving:
($0.56 / serving)
Product Weight:
9  OZ
Specialty Diets:
Gluten Free ,  Vegetarian ,  Dairy Free
Item # :
GU-1062 / 1642321

Product Reviews
   (101)

101 Ratings
4.7out of 5 stars
101 Ratings

Rated 5 stars by 83% of reviewers

Rated 4 stars by 9% of reviewers

Rated 3 stars by 3% of reviewers

Rated 2 stars by 4% of reviewers

Rated 1 star by 1% of reviewers

Customers review summary

The Primal Defense Ultra probiotic wins over customers with its multi strain, shelf stable vegetarian capsule format and a long history of people reporting clearer digestion. Customers appreciate its broad strain profile, gentle action that reduces gas and bloating for many, and the way it supports regularity, energy, and immune resilience. A few customers note initial stomach discomfort or inconsistent results with some bottles, yet most report lasting digestive relief and improved wellbeing.

AI generated from customer reviews

1-10 of 101 Reviews
Customers talk about
Feb 10, 2026
Rated 3 out of 5
Review Garden of life prebiotic Ultra.
I would rather have the original Garden of Life probiotics.
DONNA EVerified Purchaser
Location
Kasilof, AK, US
Gender
Female
Age Range
65+
Would you recommend?:Yes
Purchased on Jan 26, 2026
Was this helpful?
Sep 6, 2024
Rated 5 out of 5
Excellent results
Hi, I tried this as recommended by a PA when I was suffering from bloating and heartburn and it did the trick. I use the less expensive 416mg or 5 Billion CFU version and it works fine for me just taking 2 per day (AM and PM) versus the three recommended. VS continues to label all these 15Billion CFU for some reason, but the less expensive one is definitely labeled 416mg / 5 billion.
Johnjabischoff@gmail B
Location
San Rafael, CA
Gender
Male
Age Range
65+
Would you recommend?:Yes
Was this helpful?
Jun 24, 2023
Rated 5 out of 5
Excellent product
Excellent product
Alan LVerified Purchaser
Location
Ontario, CA, US
Gender
Male
Age Range
45-54
Would you recommend?:Yes
Purchased on Aug 3, 2020
Was this helpful?
Feb 3, 2023
Rated 5 out of 5
Great Product!!
Best I have used!
Carol RVerified Purchaser
Location
Boise, ID, US
Gender
Female
Age Range
55-64
Would you recommend?:Yes
Purchased on Apr 26, 2016
Was this helpful?
Dec 6, 2022
Rated 5 out of 5
Can?t live without
I started using these when I was in my late 20?s with digestive issues. I am now 45. I took a break 2 years ago thinking I could do without for about a year trying to save money thinking maybe they weren?t worth it. Boy was I wrong. These are worth every penny. Can?t put a price tag on being regular!
Julie WVerified Purchaser
Location
OR, US
Gender
Female
Age Range
45-54
Would you recommend?:Yes
Purchased on Sep 19, 2014
Was this helpful?
Jul 30, 2021
Rated 5 out of 5
very effective
these are very good at maintaining overall gut balance
DennisVerified Purchaser
Location
paris, TN, US
Gender
Male
Would you recommend?:Yes
Purchased on Jun 28, 2021
Was this helpful?
Apr 22, 2021
Rated 5 out of 5
Best product ever
My favorite product cannot live without it!
ANGELA WVerified Purchaser
Location
Waxhaw, NC, US
Gender
Female
Age Range
55-64
Would you recommend?:Yes
Purchased on Mar 21, 2021
Was this helpful?
Apr 14, 2021
Rated 2 out of 5
Didn't work for me
I have IBS-C and after reading the great reviews, decided to try this for my chronic constipation. It did not work. In fact it made the constipation worse. Too bad - I was so hoping it would provide me with relief. I really like Garden of Life products.
Patricia MVerified Purchaser
Location
Sarasota, FL, US
Gender
Female
Age Range
65+
Would you recommend?:No
Purchased on Mar 6, 2021
Was this helpful?
Feb 21, 2021
Rated 5 out of 5
Excellent
I have been using Primal Defense Ultra for several years now. I wouldn't be without it. It definitely assists me with my digestive issues. I highly recommend it. Garden of Life is an excellent company and has expanded over the years...very trustworthy.
Trude LVerified Purchaser
Location
Celina, OH, US
Purchased on Jan 21, 2021
Was this helpful?
Nov 20, 2020
Rated 5 out of 5
Good probiotic
I have tried a few others. I feel like Primal Defense Ultra Probiotic is definitely helping keep any stomach issues I had, away. Highly recommend!
Beth D.
Was this helpful?
Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

Q&A

We'll email them your question, then email you their replies.

Have a question? Ask owners.Have a question about this? Ask people who own it.
Start typing and see existing answers.
15 Questions
Why did you choose this?
The Vitamin ShoppeStore

Helps with acne and just overall gut health

michelle b

Not synthetic. No GI upset. Doesn’t have to be refrigerated. Reputable company.

Michele R

Help immune system

Cindy S

Quality

RANDI M
Is there an expiration date of use by date?
A shopper
Does this product contain broccoli?
A shopper

  The write up says it is gluten free but I wonder since barley contains gluten?

Lisa R

  No, I don't see it on the label.

REGINA M

  Is this product gluten free?

Deborah D.

  No

REGINA M

  Broccoli is not in the list of ingredients

James C D

Vote for the best answer above!

HOW CAN I BEST SEE A DIFFERENCE IN MY PERSONA....?
A shopper
Is this gluten free?
kathryn s

  vegetarian and gluten free are not the same. gluten free is as stated. etc. thanks though

kathryn s

  Not sure if "Ultra" is truly gluten-free, but the regular "Primal Defense" is gluten-free and states it is "Gluten-free" on the label. I'm on a strict gluten-free diet due to Celiac's and the regular Primal Defense has posed not problems to my condition.-Rena

Rena H

Thanks so much!

kathryn s

  The capsules are vegetarian, so I can only assume that they are gluten free.Hope this helps.

Ken

  Yes, the label on the bottle states "gluten free."

Jill C

Thanks!

kathryn s

Vote for the best answer above!

how many do you take per day?
A shopper

  To get the 15 bn you have to take three a day, each giving 5 bn. I take one in the morning and one at night and am fine with it. Actually wouldn't recommend taking more than one a day until your body acclimates. I don't swear by much but think this is an excellent all-around health item. Healthy gut = healthy person.

Thomas G K

  3 to 4, one with every meal. They work well but I've switched brands, InnovicLabs multi-strain probiotic. I now only take 2 a day, 1 with breakfast and 1 with dinner and seem to do much better.Garden of Life is a good brand, which I took for many years. I just decided to try something different and it worked.

Nicky W

  I take one every morning on an empty stomach. If I'm having stomach problems, I do up to three per day (before meals).

Sherry

  I take two a day--one in the morning, one at night. Have been taking them for years and they do seem to help.L

Linda G

  only one per day. If I feel a cold coming on or am traveling or have been on antibiotics I will take two.

Sarah J

  I only take 1/day now and it seems to do the trick. When I was in an acute stage, I did 2/day.

Stephanie C

  One, it is a great probiotic

Gail T

  I take three tablets daily.

Carla M

Vote for the best answer above!

how do I store it.....?
A shopper

  I store mine in the refrigerator. I think it was one of the best health decisions I ever made, to take these probiotics. Hope you find the same.

Yvonne S

  I keep it in the refrigerator, but that's not necessary. The label advises keeping it in a cool, dry place.

Lynne H

  IStore it in my dining room, if stomach acid won't destroy it, temperature will not.

Thomas S

  For longer freshness, i keep unopened bottles in fridge.

Gay B

  Once I opened it, I kept it in the fridge.

Marlene R

  I keep mine in the fridge

mark a

Vote for the best answer above!

Does this product need to be refrigerated?
Julie H

  Hi, this is Julie H, the person who posted the question. Thank you all for your responses. I decided to also contact Garden of Life customer support and here is their response: "Thank you for your email and interest in Garden of Life's products. The probiotics used in our Primal Defense formulas do not need refrigeration because they remain dormant in a dry state and only activate when they become moist. This process begins when they are ingested and so activation will begin in the gut. If the products are refrigerated once opened the probiotics may become moist, and possibly activate before they are ingested. This goes for all of our Primal Defense formulas. Please store the Primal Defense in a cool dry place such as a kitchen cabinet/pantry."

Julie H

  when I purchase this at my local health food stores, it is always in a cooler shelving unit, but not a actual refrigerator, but I do keep mine in my refrigerator at home. I always think any live probiotic should be refrigerated. But let be know if you know something different.Karen

Karen L

  The product label says to store in a cool dry place so you do not have to refrigerate this product. I usually store it in my pantry.

Romina R

  It is better if refrigerated.

Randi M

Vote for the best answer above!

Is this safe to use everyday?
A shopper

  Like with any probiotic, use and adjust based on your condition. Too much can cause bloating, so you need to give your system time to adjust. Garden of life offers great quality, but like with any supplement, always try and see how you feel. You may decide to take it every day or once a week. Remember that everyone's digestive system is unique.

irina s

  Yes I take it everyday for the past couple of years !

Robert E

  Yes

Malinda J

Vote for the best answer above!

Does this probiotic have inulin or milk product?
A shopper

  The capsules are vegetarian. I do not see inulin anywhere on the label, but I am not familiar with it. You may want to Google "Garden of Life" to make sure.

Cheryl R

I just saw the other reply about it being cultured in dairy. Yes, it is.

Cheryl R

  Cultured in dairy

Vickie V

Vote for the best answer above!

can a 12 year old take these?
A shopper

  They are the strongest. I see no reason why not. Not sure why you want a child to take but if not a medical type issue and just general health save money and get the regular ones.

Victoria

  best to check with your doctor/naturopath

mg

Vote for the best answer above!

Questions for Similar Products
Does this probiotic have to be refrigerated?
Primal Defense Ultra
About
Primal Defense Ultra
Jessica

  Does not need refrigeration, I just keep mine in a kitchen cupboard away from heat

Sydney

  No. Just kept away from heat. I keep them in the pantry.

John J

  No. I just keep it on the shelf above my kitchen sink.

Debra B

  No,it does not.

Gina N

  No

Allen F

Vote for the best answer above!

Does this product contain both pre and probiotics?
Primal Defense Ultra
About
Primal Defense Ultra
Sarah

  No. If you are looking for prebiotic & probiotic then it would say so on the box. Other brands do sell both in one!

Michelle R

  Hi it only has probiotics.

Romina R.

  Hi,

Romina R.

Vote for the best answer above!

Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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Probiotics have earned a reputation as all-stars for foundational health. Found in capsules, gummies, teas, and, of course, fermented foods like yogurt and sauerkraut, these beneficial bacteria have been linked with all sorts of wellness perks, from reducing constipation to supporting healthy blood sugar.

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