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Primal Defense ULTRA – Ultimate Probiotic Formula – 15 Billion CFU (216 Vegetarian Capsules)

Rated 4.8 out of 5
33 Reviews|5 Questions | 304 Answers|
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      Gluten FreeVegetarian
      GET ADVICE FROM A HEALTH ENTHUSIAST
      $81.99
      ($0.37/serving)

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      • One Flavor
      • 15 BILLION
      • 216 Capsules$81.99
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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      Primal Defense ULTRA – Ultimate Probiotic Formula – 15 Billion CFU (216 Vegetarian Capsules)
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      Product Info

      About This Product

      • Primal Defense 15 billion CFU probiotic supplement has Lactobaccilus acidophilus, Bifidobacteria and other strains to maximize the benefits of a healthy diet, boost nutrient absorption, relieve constipation & support digestive health
      • The only shelf stable probiotic powder formula contains soil based probiotics like Homeostatic Soil Organisms (HSO)
      • This probiotics Garden of Life has 15 billion CFU and 13 hardy beneficial strains for system health
      • These probiotics for constipation promote regular, healthy and comfortable bowel movements
      • Whole food, gluten free, vegetarian bifidobacterium probiotics supplement for a balanced, health internal environment

      It combines the benefits of 15 billion CFU and 13 robust strains, including the renowned lactobacillus acidophilus. The inclusion of SBO probiotics, such as Homeostatic Soil Organisms. Designed to fit into your regimen of supplements for women and men, it acts as probiotics for men and women that promote digestive health by supporting a balanced internal environment. By supporting regular digestive function and immune resilience, Primal Defense Ultra is a great choice for maintaining your body's natural defenses. Contains Bacillus subtilis to support healthy lactic acid bacteria (Bifidobacterium and/or Lactobacillus) count and healthy pH levels in the gut. The Saccharomyces boulardii in Primal Defense Ultra nourishes intestinal mucosa cells to support the normal barrier function of the intestinal epithelium, the front line for the body's defense system.

      †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

      Read More

      Directions

      Adults begin with 1 capsule per day with 8oz. of water and gradually increase to 1 capsule 3 times per day. Best taken on an empty stomach. Not intended for children.

      Warning

      As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, anticipate surgery, take medication on a regular basis or are otherwise under medical supervision. Keep out of reach of children. Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep out of reach of children. In case of accidental overdose, call a physician or poison control center immediately.

      Updated Jan 15, 2026
      Read More

      Supplement Facts

      Serving Size: 1 Capsule
      Number of Servings: 216 Servings
      Amount Per Serving
      % Daily Value
      IRON FROM IONIC PLANT BASED MINERALS   
      2 MG
      10%
      HSO PROBIOTIC BLEND  - 5 BILLION CFU
      410 MG
      N/A*
      SACCHAROMYCES BOULARDII   
      0 
      N/A*
      ORGANIC BARLEY GRASS   
      0 
      N/A*
      ORGANIC OAT GRASS   
      0 
      N/A*
      LACTOBACILLUS PLANTARUM   
      0 
      N/A*
      BACILLUS SUBTILIS   
      0 
      N/A*
      BIFIDOBACTERIUM LACTIS   
      0 
      N/A*
      BIFIDOBACTERIUM BIFIDUM   
      0 
      N/A*
      LACTOBACILLUS RHAMNOSUS   
      0 
      N/A*
      BIFIDOBACTERIUM BREVE   
      0 
      N/A*
      LACTOBACILLUS CASEI   
      0 
      N/A*
      LACTOBACILLUS SALIVARIUS   
      0 
      N/A*
      LACTOBACILLUS ACIDOPHILUS   
      0 
      N/A*
      LACTOBACILLUS BREVIS   
      0 
      N/A*
      BIFIDOBACTERIUM LONGUM   
      0 
      N/A*
      LACTOBACILLUS PARACASEI   
      0 
      N/A*
      IONIC PLANT BASED MINERALS   
      290 MG
      N/A*

      Other Ingredients:

      Vegetable cellulose (capsule), organic rice (hull).

      Does Not Contain:

      Preservative Free, Free of Artificial Colors

      How Do You Read A Supplement Facts Label?

      Specifications

      Brand:
      Garden of Life
      Form:
      Capsules
      Serving Size:
      1 Capsule
      Number of Servings:
      216 Servings
      Price per Serving:
      ($0.38 / serving)
      Product Weight:
      9  OZ
      Specialty Diets:
      Gluten Free ,  Vegetarian
      Item # :
      GU-1184 / 1989185

      Product Reviews
         (33)

      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

      33 Ratings
      4.8out of 5 stars
      33 Ratings

      Rated 5 stars by 94% of reviewers

      594%

      Rated 4 stars by 0% of reviewers

      40%

      Rated 3 stars by 3% of reviewers

      33%

      Rated 2 stars by 3% of reviewers

      23%

      Rated 1 star by 0% of reviewers

      10%
      Would you recommend?
      1-10 of 33 Reviews
      • checkMost Recent
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      • (31)
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      • Under 18 (0)
      • 18-24 (0)
      • 25-34 (1)
      • 35-44 (1)
      • 45-54 (2)
      • 55-64 (2)
      • 65+ (3)
      Feb 10, 2026
      Rated 3 out of 5
      Review Garden of life prebiotic Ultra.
      I would rather have the original Garden of Life probiotics.
      DONNA EVerified Purchaser
      Location
      Kasilof, AK, US
      Gender
      Female
      Age Range
      65+
      Would you recommend?:Yes
      Purchased on Jan 26, 2026
      Was this helpful?
      Review by DONNA E has been flagged
      Flag
      Sep 6, 2024
      Rated 5 out of 5
      Excellent results
      Hi, I tried this as recommended by a PA when I was suffering from bloating and heartburn and it did the trick. I use the less expensive 416mg or 5 Billion CFU version and it works fine for me just taking 2 per day (AM and PM) versus the three recommended. VS continues to label all these 15Billion CFU for some reason, but the less expensive one is definitely labeled 416mg / 5 billion.
      Johnjabischoff@gmail B
      Location
      San Rafael, CA
      Gender
      Male
      Age Range
      65+
      Would you recommend?:Yes
      Was this helpful?
      Review by Johnjabischoff@gmail B has been flagged
      Flag
      Jun 24, 2023
      Rated 5 out of 5
      Excellent product
      Excellent product
      Alan LVerified Purchaser
      Location
      Ontario, CA, US
      Gender
      Male
      Age Range
      45-54
      Would you recommend?:Yes
      Purchased on Aug 3, 2020
      Was this helpful?
      Review by Alan L has been flagged
      Flag
      Dec 6, 2022
      Rated 5 out of 5
      Can?t live without
      I started using these when I was in my late 20?s with digestive issues. I am now 45. I took a break 2 years ago thinking I could do without for about a year trying to save money thinking maybe they weren?t worth it. Boy was I wrong. These are worth every penny. Can?t put a price tag on being regular!
      JulieVerified Purchaser
      Location
      OR, US
      Gender
      Female
      Age Range
      45-54
      Would you recommend?:Yes
      Purchased on Sep 19, 2014
      Was this helpful?
      Review by Julie has been flagged
      Flag
      Feb 21, 2021
      Rated 5 out of 5
      Excellent
      I have been using Primal Defense Ultra for several years now. I wouldn't be without it. It definitely assists me with my digestive issues. I highly recommend it. Garden of Life is an excellent company and has expanded over the years...very trustworthy.
      TrudeVerified Purchaser
      Location
      Celina, OH, US
      Purchased on Jan 21, 2021
      Was this helpful?
      Review by Trude has been flagged
      Flag
      May 13, 2020
      Rated 5 out of 5
      Great Probiotic
      Primal Defense has kept my husband off his old GIRD medicine for many years now. So grateful.
      Michelle B.
      Originally posted at Garden Of Life
      Was this helpful?
      Review by Michelle B. has been flagged
      Flag
      May 8, 2020
      Rated 5 out of 5
      Excellent product. Always delivered on
      Excellent product. Always delivered on time.
      Gary R.
      Originally posted at Garden Of Life
      Was this helpful?
      Review by Gary R. has been flagged
      Flag
      Mar 19, 2020
      Rated 5 out of 5
      Primal Defense Ultra
      My husband & I have been using Primal Defense Ultra for over 10yrs. I never had such good results with any other probiotic. This is the only probiotic that keeps me from getting bloated & I love my flat tummy.
      Cynthia M.
      Originally posted at Garden Of Life
      Was this helpful?
      Review by Cynthia M. has been flagged
      Flag
      Mar 4, 2020
      Rated 5 out of 5
      Excellent Probiotic
      I really like this SBO probiotic
      Jennifer K.
      Originally posted at Garden Of Life
      Was this helpful?
      Review by Jennifer K. has been flagged
      Flag
      Feb 24, 2020
      Rated 5 out of 5
      Great Probiotic!
      Love this probiotic, great price too.... Definitely felt it made a big difference during cold and flu season! Would highly recommend !!!
      SydneyVerified Purchaser
      Location
      Kennewick, WA, US
      Gender
      Female
      Age Range
      25-34
      Would you recommend?:Yes
      Purchased on Jan 24, 2020
      Was this helpful?
      Review by Sydney has been flagged
      Flag
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      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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      5 Questions
      Most Recent Question
      Oldest Question
      Most Common
      Most Answers
      Fewest Answers
      Most Recent Answer
      Oldest Answer
      Why did you choose this?
      The Vitamin ShoppeStore

      Great product, works well. Been taking this product for years.

      Gayle MJun 28, 2026

      I have been using this product for over 25 years.

      Susan SJun 14, 2026

      I need it

      David WJun 5, 2026

      I need it

      David WJun 5, 2026
      Does this probiotic have to be refrigerated?
      JessicaAug 9, 2019

      Best Answer:  Does not need refrigeration, I just keep mine in a kitchen cupboard away from heat

      SydneyFeb 24, 2020purchased Jan 24, 2020
      Reply
      Inaccurate
      Answer by Sydney has been flagged
      What is the shelf life of this product? Does it expire?
      ChadApr 26, 2022

      Best Answer:  All supplements would expire at some time. This supplement commonly has a shelf life of around 12 months, and an expiration date should be listed around the rim of the bottle or on the bottom.

      Daniel W.staffApr 26, 2022
      Reply
      Inaccurate
      Answer by Daniel W. has been flagged
      Is this product gluten free?
      Diana GOct 10, 2016

      Best Answer:  Yes. It says this in the product description. It's a great product. I've been taking it for about 10 years now.

      Bruce BOct 10, 2016purchased Oct 27, 2014
      Reply
      Inaccurate
      Answer by Bruce B has been flagged
      Is this shipped with ice?
      A shopperJun 21, 2016

      Best Answer:  Thank you for this question. Our products do not ship on ice. All of our refrigerated products are only available in store. Have a happy and healthy day! -Francesco

      Francesco A.staffJun 28, 2016
      Reply
      Inaccurate
      Answer by Francesco A. has been flagged
      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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      FREE STANDARD SHIPPING on orders of $45 or more

      How to get FREE Standard Shipping:

      1. Ship to an address within the United States (including U.S. territories)
      2. Place your online order of $45 or more* - after promotions and before tax are applied
      3. Use "Standard" shipping option at checkout

      Orders will be shipped within 24 hours of order placement*, pending verification of billing information and shipping method selected. International orders and orders containing gift cards or items that are not currently in stock will be processed as quickly as possible.

       

      *Excludes all orders placed on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day).

       

      Orders for states outside of the continental U.S. (including those of $45 or more) may be subject to a delivery surcharge. This will be noted in the order summary based on your shipping address at checkout.

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      Experts Break it Down

      The Best And Worst Time Of Day To Take Your Probiotics

      The Best And Worst Time Of Day To Take Your Probiotics

      Given their many benefits, it’s no wonder many of us have added probiotic supplements to our daily routines. Thing is, benefiting from a supplement isn’t quite as simple as just remembering to take it at some point every day.

      The Ultimate Guide To Taking Probiotics

      The Ultimate Guide To Taking Probiotics

      Probiotics have long been considered foundational to a healthy routine, but despite their lengthy history as a mainstream supplement, there’s still plenty of confusion. f you could use some clarification on the puzzle of probiotics, read on. This expert-approved guide has the a’s to your microbiota q’s.

      How To Pair Your Probiotics With Herbs For Ultimate Gut Support

      How To Pair Your Probiotics With Herbs For Ultimate Gut Support

      In terms of gut support, herbal solutions tend not to get as much attention as probiotics, but emerging research suggests they’re unsung supporting actors.

      Can Probiotics Really Boost Your Mood?

      Can Probiotics Really Boost Your Mood?

      Probiotics have earned a reputation as all-stars for foundational health. Found in capsules, gummies, teas, and, of course, fermented foods like yogurt and sauerkraut, these beneficial bacteria have been linked with all sorts of wellness perks, from reducing constipation to supporting healthy blood sugar.

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      HomeDigestion & Gut HealthProbioticsPrimal Defense ULTRA – Ultimate Probiotic Formula – 15 Billion CFU (216 Vegetarian Capsules)

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      By creating an account, you agree to the Healthy Awards Terms and Conditions , Auto Delivery Terms and Conditions and the Vitamin Shoppe's Terms of Use and Privacy Policy. If you are a California or Colorado resident, you agree that you are enrolling in a financial incentive/loyalty program and acknowledge that you have read and understand the Financial Incentive and Loyalty Program Notice.

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      Ready to get your V.I.P. on? Fill out the info below and we’ll kickstart your membership with 25 FREE bonus points towards a Cash Back Award.

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      By creating an account, you agree to the Healthy Awards Terms and Conditions , Auto Delivery Terms and Conditions and the Vitamin Shoppe's Terms of Use and Privacy Policy. If you are a California or Colorado resident, you agree that you are enrolling in a financial incentive/loyalty program and acknowledge that you have read and understand the Financial Incentive and Loyalty Program Notice.

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      Thanks for joining the family. Now you get points on every purchase—towards Cash Back Awards—plus, access to the Rewards Center with free points activities every month, giveaways, and oh yeah… those 25 bonus points will be in your account by tomorrow.

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      Buy one, get one 50% off Garden of Life brand products. Offer valid 07/27/2026 through 08/09/2026. Discount taken off price of second item of equal or lesser value. Excludes clearance items.
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      Buy one, get one 50% off Garden of Life brand products. Offer valid 07/27/2026 through 08/09/2026. Discount taken off price of second item of equal or lesser value. Excludes clearance items.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.