NR Longevity is specially designed to target biological processes that decline with age, such as the body’s natural ability to make energy, build new mitochondria and protect cells from oxidative stress. Nicotinamide riboside (NR), resveratrol and sulforaphane promote healthy aging by replenishing NAD+, enhancing mitochondrial function and providing antioxidant support, respectively. Nicotinamide riboside (NR) is a form of vitamin B³ that acts as a precursor of nicotinamide adenine dinucleotide (NAD+), which plays a critical role in cellular energy production. NAD+ activates enzymes in the sirtuin family, considered to be master switches of metabolism and regulators of aging. Notably, NAD+ activates SIRT1, an epigenetic switch that regulates metabolism and supports mitochondrial biogenesis, cellular energy production and cellular longevity. Higher NAD+ levels are associated with healthy mitochondrial function. Conversely, cellular NAD+ levels decline with age, and can decrease by up to 50% over the adult lifespan. Supplementing with NR enhances NAD+ levels, supporting the function of NAD+ dependent enzymes that maintain cellular energy production and repair. NR has been clinically shown to increase NAD+ levels in as little as 2 weeks. Resveratrol and sulforaphane promote longevity in model organisms. Both compounds enhance cellular antioxidant defenses, helping to protect cells against oxidative stress that increases with age and contributes to age-related cellular decline. Resveratrol activates the AMPK/SIRT1/PGC-1alpha axis, a pathway that enhances mitochondrial function and supports normal cellular repair while sulforaphane activates Nrf2, a genomic switch that stimulates expression of genes involved in antioxidant defense, cellular protection and mitochondrial biogenesis. Nrf2 is a transcription factor that supports robust, long-lasting expression of numerous genes responsible for phase II detoxification and protection against oxidative stress. Among these genes are glutathione peroxidase, superoxide dismutase and various phase II enzymes, such as glutathione sulfotransferases. Nrf2 also supports expression of glutathione glutamylcysteinyl ligase, which is responsible for a critical step in the biosynthesis of glutathione, a vital component of cellular antioxidant and detoxification systems.

• Supports increased NAD+
• Promotes healthy aging

Tru Niagen is formulated to support increased NAD+ levels in the blood with 300mg of NIAGEN^®. NAD+, or nicotinamide adenine dinucleotide, supports the production of cellular energy and aids in cellular repair to promote healthy aging.

Frequently Asked Questions

What is NIAGEN? NIAGEN

is a patented form of nicotinamide riboside, which is a member of the vitamin B3 family.

• Advanced defense against cellular aging
• Non-GMO and gluten-free

Defy aging and fight general fatigue at the cellular level with NAD+ Cell Regenerator from Life Extension. This NIAGEN^® formula promotes the production of NAD+, a cellular coenzyme that supports healthy cellular metabolism and facilitates energy production.

Frequently Asked Questions

What is NIAGEN?

NIAGEN is a patented form of nicotinamide riboside, a member of the vitamin B3 family.

• Defense against cellular aging
• Non-GMO and gluten-free

Combat aging at the cellular level with NAD+ Cell Regenerator and Resveratrol from Life Extension. This advanced formula features NIAGEN^® to promote the production of NAD+ for increased cellular energy, plus resveratrol to support healthy aging and overall wellness.

Frequently Asked Questions

What is NIAGEN?

NIAGEN is a patented form of nicotinamide riboside, a member of the vitamin B3 family.

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a molecule that plays a critical role in supporting mitochondria and proper cell function.

What is resveratrol?

Resveratrol is a natural compound found in fruits such as grapes and berries. It's believed to have longevity-supporting properties.