Methyl Folate (6S) 5-methyl tetrahydrofolate or 5-MTHF) is the most biologically active form of folic acid.

QUATREFOLIC is the 4th generation development in folate delivery. With certain inherited errors in metabolism and under a variety of physiologic stresses, the transformation of Folic Acid into the active form of folate either does not properly take place or is inadequate. Unlike folic acid, this form of folate can cross the blood-brain barrier. Methyl Folate is needed to support cardiovascular and neurologic health and proper cell division. Folate supplementation duting pregnancy has been shown to reduce the risk of neutral tube birth defects.

Brain Better with Neuriva

We're the brain's biggest fan, so we're on a mission to help all brains be the best they can be. Which is why we didn't just stop with an awesome supplement. Our holistic brain-health regimen includes tips, tools and training designed to help you brain better.

Because when your brain wins, you win.

Fuels 6 indicators of brain performance:

• Focus: Zoom in and filter out distractions
• Memory: Record and recall stored information better
• Learning: Retain and integrate new information
• Accuracy: React with greater speed and precision
• Concentration: Stay on task longer
• Reasoning: Think and understand things in a logical way

Nature made it. Science proved it. Brains love it.

Our naturally sourced ingredients are GMO-free and clinically proven to enhance brain performance. Disclaimer: Neuriva won't make you a genius, but others might think you are.

• NEUROFACTOR (COFFEE CHERRY): Made from the nutrient-rich fruit of the coffee cherry, this whole fruit extract is decaffeinated and clinically proven to increase levels of the vital neuroprotein BDNF, known to strengthen connections between brain cells.
• PLANT-SOURCED SHARP PS (PHOSPHATIDYLSERINE): These plant-sourced phopholipids make up the structure of neurons within the brain. Clinically proven to aid neuron health and fuel memory and learning ability.
• VITAMINS B6, B12 & FOLIC ACID: Key nutrients to support brain health & cognitive function

• Supports cardiovascular and brain health
• Helps maintain healthy homocysteine levels
• Non-GMO and gluten-free

Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This formula features 1,700mcg of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

Frequently Asked Questions

What is homocysteine?

Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

What does “bioavailable” mean?

When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

• Support energy production
• Supports nutrient metabolism
• Suitable for everyday wellness seekers
• Contains 500mg of pantothenic acid per serving (that exceeds your daily requirement!)
• Free of gluten, diary, soy, nuts, sugar, salt, preservatives, and artificial colors or flavors