Optimized Folate – L-Methylfolate – 1,700 MCG (100 Vegetarian Tablets)

Optimized Folate – L-Methylfolate – 1,700 MCG (100 Vegetarian Tablets)

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About This Product

  • Supports cardiovascular and brain health
  • Helps maintain healthy homocysteine levels
  • Non-GMO and gluten-free

Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This formula features 1,700mcg of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

Frequently Asked Questions

What is homocysteine?

Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

What does “bioavailable” mean?

When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

Read More

Directions

Take one tablet daily with food, or as recommended by a healthcare practitioner.

Warning

Keep out of reach of children. Do not exceed recommended dose. When using nutritional supplements, please consult with your physician if you are undergoing treatment for medical condition or if you are pregnant or lactating.

Read More
Serving Size: 1 Tablet
Number of Servings: 100 Servings
Amount Per Serving
% Daily Value
FOLATE  - (AS (6S)-5-METHYLTETRAHYDROFOLIC ACID, GLUCOSAMINE SALT)
425%

Other Ingredients:

Microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.

Brand:
Life Extension
Form:
Tablet(s)
Strength:
1700 MCG
Serving Size:
1 Tablet
Number of Servings:
100 Servings
Price per Serving:
($0.20 / serving)
Product Weight:
2  OZ
Specialty Diets:
Gluten Free ,  Non-GMO
Item # :
UX-1068 / 1872936
109 Ratings
4.7out of 5 stars
109 Ratings

Rated 5 stars by 83% of reviewers

Rated 4 stars by 8% of reviewers

Rated 3 stars by 6% of reviewers

Rated 2 stars by 2% of reviewers

Rated 1 star by 1% of reviewers

Would you recommend?
1-10 of 109 Reviews
Rated 4 out of 5
Apr 26, 2026
Got just what I ordered
Timely shipping and accurate order
Rated 5 out of 5
Sep 26, 2025
Best on the market
Best Folate supplement available at a great price.
Rated 5 out of 5
Jun 25, 2025
Good place to get health supplements
Easiest way to get a supplement that he needs. Quick service and fast shipping
Rated 3 out of 5
Jun 18, 2025
It must be okay, because I'm not feeling worse.
I'm mostly anti-supplement except for medical reasons (i.e., a diagnosed deficiency or genetic metabolic issue) because I'm a big skeptic: I need peer-reviewed, repeatible studies. So I can only go off of this: I have an MTHFR gene issue of "moderate severity" via the test my psychiatrist had done for me, which is supposed to predict how well your body can metabolize antidepressants and such. I was told to take exactly this supplement, and I'm glad I was pointed here because it seems to be a more effective form and affordable. Little do people know, due to sneaky marketing tactics, that a higher price tag doesn't always mean a higher efficacy or even quality, and more isn't always better!

Anyway, I couldn't tell you if anything's different since I started taking it, but I intend to continue to do so, as long as it appears it might help, and I undergo medication tweaks every now and then. I don't get any upper digestive symptoms when I take this. It's hard to choke down sometimes, though. I try to use really cold water that helps numb my throat and mouth and kind of trick my brain. A handful of times, though, I've really coughed that sucker up and it was miserable. The sharp edges and lack of coating are the main thing, I think, plus once it starts dissolving it tastes terrible, of course. I hope a better form or at least shape is already being looked into!
Rated 5 out of 5
May 24, 2025
Highly recommended
Excellent supplement. I'm a regular buyer
Rated 5 out of 5
Apr 1, 2025
Just What I Need
Taking for deficiency caused by genetic defect.
Rated 5 out of 5
Mar 29, 2025
Folate, Methyl-folate to keep homocysteine in healthy range
I particularly cherish the optimized Folate, Merhyl-folate.
Rated 5 out of 5
Feb 25, 2025
Works great !
I have the MFTHFR gene and this is something I need for it ! Works great for me !
Rated 5 out of 5
Dec 31, 2024
Absorption is very important for a body
Buy for the quality as it has great absorption. Without that, I would be missing out on getting its full benefit, right?
Rated 5 out of 5
Oct 13, 2024
Trusted quality
Easy to swallow, great product, trusted brand
Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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2 Questions
Why did you choose this?

Dr's orders

Advised by OBGYN for low Folate.

dr. recommended

Following doctors orders

Is this similar to metanx prescription vitamin?

Best Answer:  L-methylfolate is one of about 4 or 5 ingredients in metanx. Metanx also has the non cyanide bound form of B12 and has calcium in it. These ingredients together are thought to help neuropathy in diabetics.

Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

 

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    High Potency Optimized Folate – L-Methylfolate – 8,500
    • Supports cardiovascular and brain health
    • Helps maintain healthy homocysteine levels
    • Provides 8,500mcg of 5-MTHF per serving
    • Non-GMO and gluten-free

    High Potency Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This potent formula features a high 8,500mcg dose of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

    Frequently Asked Questions

    What is homocysteine?

    Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

    What does “bioavailable” mean?

    When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

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