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Optimized Folate – L-Methylfolate – 1,700 MCG (100 Vegetarian Tablets)

Optimized Folate – L-Methylfolate – 1,700 MCG (100 Vegetarian Tablets)

$19.99
($0.19/serving)

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Optimized Folate – L-Methylfolate – 1,700 MCG (100 Vegetarian Tablets)

Rated 4.7 out of 5
110 Reviews|2 Questions | 138 Answers|
Life Extension Optimized Folate Vegetarian Tablets 1700 MCG bottle front
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  • Life Extension Optimized Folate Vegetarian Tablets 1700 MCG bottle front
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      Gluten FreeNon-GMO
      GET ADVICE FROM A HEALTH ENTHUSIAST
      $19.99
      ($0.19/serving)

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      • 1700 MCG
      • 8500 MCG
      • 100 Tablet(S)$19.99
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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      Life Extension
      Optimized Folate – L-Methylfolate – 1,700 MCG (100 Vegetarian Tablets)
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      Product Info

      About This Product

      • Supports cardiovascular and brain health
      • Helps maintain healthy homocysteine levels
      • Non-GMO and gluten-free

      Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This formula features 1,700mcg of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

      Frequently Asked Questions

      What is homocysteine?

      Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

      What does “bioavailable” mean?

      When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

      Read More

      Directions

      Take one tablet daily with food, or as recommended by a healthcare practitioner.

      Warning

      Keep out of reach of children. Do not exceed recommended dose. When using nutritional supplements, please consult with your physician if you are undergoing treatment for medical condition or if you are pregnant or lactating.

      Updated Jan 15, 2026
      Read More

      Supplement Facts

      Serving Size: 1 Tablet
      Number of Servings: 100 Servings
      Amount Per Serving
      % Daily Value
      FOLATE  - (AS (6S)-5-METHYLTETRAHYDROFOLIC ACID, GLUCOSAMINE SALT)
      1,700 MCG
      425%

      Other Ingredients:

      Microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.

      How Do You Read A Supplement Facts Label?

      Specifications

      Brand:
      Life Extension
      Form:
      Tablet(s)
      Strength:
      1700 MCG
      Serving Size:
      1 Tablet
      Number of Servings:
      100 Servings
      Price per Serving:
      ($0.20 / serving)
      Product Weight:
      2  OZ
      Specialty Diets:
      Gluten Free ,  Non-GMO
      Item # :
      UX-1068 / 1872936

      Product Reviews
         (110)

      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

      110 Ratings
      4.7out of 5 stars
      110 Ratings

      Rated 5 stars by 84% of reviewers

      584%

      Rated 4 stars by 8% of reviewers

      48%

      Rated 3 stars by 5% of reviewers

      35%

      Rated 2 stars by 2% of reviewers

      22%

      Rated 1 star by 1% of reviewers

      11%
      Would you recommend?
      1-10 of 110 Reviews
      • checkMost Recent
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      • (92)
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      • 18-24 (0)
      • 25-34 (0)
      • 35-44 (0)
      • 45-54 (0)
      • 55-64 (1)
      • 65+ (0)
      Customers talk about
      AI analysis found these key themes mentioned in reviews.
      Jun 5, 2026
      Rated 5 out of 5
      Awesome Product
      I love this product
      Marie
      Location
      Johnstown PA
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Marie has been flagged
      Flag
      Apr 26, 2026
      Rated 4 out of 5
      Got just what I ordered
      Timely shipping and accurate order
      REBECCA
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by REBECCA has been flagged
      Flag
      Sep 26, 2025
      Rated 5 out of 5
      Best on the market
      Best Folate supplement available at a great price.
      MICHELINE
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by MICHELINE has been flagged
      Flag
      Jun 25, 2025
      Rated 5 out of 5
      Good place to get health supplements
      Easiest way to get a supplement that he needs. Quick service and fast shipping
      REBECCA
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by REBECCA has been flagged
      Flag
      Jun 18, 2025
      Rated 3 out of 5
      It must be okay, because I'm not feeling worse.
      I'm mostly anti-supplement except for medical reasons (i.e., a diagnosed deficiency or genetic metabolic issue) because I'm a big skeptic: I need peer-reviewed, repeatible studies. So I can only go off of this: I have an MTHFR gene issue of "moderate severity" via the test my psychiatrist had done for me, which is supposed to predict how well your body can metabolize antidepressants and such. I was told to take exactly this supplement, and I'm glad I was pointed here because it seems to be a…
      Satisfied Skeptic
      Location
      Wisconsin
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Satisfied Skeptic has been flagged
      Flag
      May 24, 2025
      Rated 5 out of 5
      Highly recommended
      Excellent supplement. I'm a regular buyer
      Marcos
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Marcos has been flagged
      Flag
      Apr 1, 2025
      Rated 5 out of 5
      Just What I Need
      Taking for deficiency caused by genetic defect.
      Katherine
      Location
      Undisclosed
      Originally posted at Life Extension
      Was this helpful?
      Review by Katherine has been flagged
      Flag
      Mar 29, 2025
      Rated 5 out of 5
      Folate, Methyl-folate to keep homocysteine in healthy range
      I particularly cherish the optimized Folate, Merhyl-folate.
      David
      Location
      Undisclosed
      Originally posted at Life Extension
      Was this helpful?
      Review by David has been flagged
      Flag
      Feb 25, 2025
      Rated 5 out of 5
      Works great !
      I have the MFTHFR gene and this is something I need for it ! Works great for me !
      Theresa
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Theresa has been flagged
      Flag
      Dec 31, 2024
      Rated 5 out of 5
      Absorption is very important for a body
      Buy for the quality as it has great absorption. Without that, I would be missing out on getting its full benefit, right?
      PHILLIP
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by PHILLIP has been flagged
      Flag
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      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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      2 Questions
      Why did you choose this?
      The Vitamin ShoppeStore

      Apparently this will make my b12 better

      Eileen GJun 22, 2026

      Dr's orders

      scott bMar 25, 2026

      Advised by OBGYN for low Folate.

      Jessica PJan 24, 2026

      dr. recommended

      Ann marilyn SDec 8, 2025
      Is this similar to metanx prescription vitamin?
      A shopperSep 8, 2015

      Best Answer:  L-methylfolate is one of about 4 or 5 ingredients in metanx. Metanx also has the non cyanide bound form of B12 and has calcium in it. These ingredients together are thought to help neuropathy in diabetics.

      Melody DAug 5, 2017purchased Jan 20, 2016
      Reply
      Inaccurate
      Answer by Melody D has been flagged
      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

      Shipping Info

       

      FREE STANDARD SHIPPING on orders of $45 or more

      How to get FREE Standard Shipping:

      1. Ship to an address within the United States (including U.S. territories)
      2. Place your online order of $45 or more* - after promotions and before tax are applied
      3. Use "Standard" shipping option at checkout

      Orders will be shipped within 24 hours of order placement*, pending verification of billing information and shipping method selected. International orders and orders containing gift cards or items that are not currently in stock will be processed as quickly as possible.

       

      *Excludes all orders placed on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day).

       

      Orders for states outside of the continental U.S. (including those of $45 or more) may be subject to a delivery surcharge. This will be noted in the order summary based on your shipping address at checkout.

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      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.