High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

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About This Product

  • Supports cardiovascular and brain health
  • Helps maintain healthy homocysteine levels
  • Provides 8,500mcg of 5-MTHF per serving
  • Non-GMO and gluten-free

High Potency Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This potent formula features a high 8,500mcg dose of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

Frequently Asked Questions

What is homocysteine?

Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

What does “bioavailable” mean?

When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

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Directions

Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

Warning

Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician. Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

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Serving Size: 1 Tablet
Number of Servings: 30 Servings
Amount Per Serving
% Daily Value
FOLATE  - AS (6S)-5-METHYLTETRAHYDROFOLATE, CALCIUM SALT
2125%

Other Ingredients:

Microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.

Brand:
Life Extension
Form:
Vegetarian Tablets
Strength:
8500 MCG
Serving Size:
1 Tablet
Number of Servings:
30 Servings
Price per Serving:
($0.63 / serving)
Product Weight:
1  OZ
Specialty Diets:
Gluten Free ,  Non-GMO
Item # :
UX-13095 / 2295632
50 Ratings
4.8out of 5 stars
50 Ratings

Rated 5 stars by 84% of reviewers

Rated 4 stars by 10% of reviewers

Rated 3 stars by 4% of reviewers

Rated 2 stars by 2% of reviewers

Rated 1 star by 0% of reviewers

Would you recommend?
1-10 of 50 Reviews
Rated 5 out of 5
Oct 13, 2025
TMG
Awesome
Rated 5 out of 5
Jul 29, 2025
This helps calm my busy mind at night
I learned this trick from Dr. Paul Saladino to take L-Methylfolate at night if you have genetic variants in the MTHFR and COMT. I often have issues with "wide awake" brain at bedtime as I'm not good at breaking down catecholamines including dopamine. This has been helping me sleep better immensely!!
Rated 2 out of 5
Oct 23, 2024
Great Product.....Packaging Sucks
I take this every day. It's the only thing getting my homocysteine levels in the normal range. I can only buy 30 pills at once in a bottle that could easily hold 300. The amount of plastic going into the landfill by me taking this product is depressing. I need it for my health...the planter's health would fare better if this was offered in 90 or 120 pills per bottle or even larger ..
Rated 5 out of 5
Aug 1, 2024
Great Product
This is such a great product! I would recommend to take it everyday for overall health.
Rated 5 out of 5
Jul 11, 2024
Good quality and prices
Delivered in a timely manner
Rated 5 out of 5
May 31, 2024
Folic Acid
Great product that is affordable.
Rated 5 out of 5
May 14, 2024
Happy to Have
My son swears by this. It helps his mental health!
Rated 5 out of 5
May 14, 2024
For Quick Hair Growth...
My hair has grown longer and thicker quicker than any other vitamin I've ever used, like Biotin. I highly recommend this Life Extension product!!!
Rated 5 out of 5
Dec 5, 2022
Works great!
This supplement was recommended by my OBGYN and has proven an immense help with my pregnancies. Very satisfied.
Rated 5 out of 5
Jul 6, 2022
The best folate ever!!
Recommended to me by my med provider. Works great! Its the only folate my body will assimilate.
Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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1 Question
Why did you choose this?

Doc recommended ha.

Dr recommended based on patient’s results

In-store recommendation

Recommended by Dr

Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

 

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    • Supports cardiovascular and brain health
    • Helps maintain healthy homocysteine levels
    • Non-GMO and gluten-free

    Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This formula features 1,700mcg of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

    Frequently Asked Questions

    What is homocysteine?

    Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

    What does “bioavailable” mean?

    When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

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