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High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

$18.99
($0.63/serving)

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High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

Rated 4.7 out of 5
162 Reviews|2 Questions | 14 Answers|
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    Main Product
      Gluten FreeNon-GMO
      GET ADVICE FROM A HEALTH ENTHUSIAST
      $18.99
      ($0.63/serving)

      AUTO DELIVERY SAVE 15%

      • 8500 MCG
      • 1700 MCG
      • 30 Vegetarian Tablets$18.99
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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      Life Extension
      High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)
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      Product Info

      About This Product

      • Supports cardiovascular and brain health
      • Helps maintain healthy homocysteine levels
      • Provides 8,500mcg of 5-MTHF per serving
      • Non-GMO and gluten-free

      High Potency Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This potent formula features a high 8,500mcg dose of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

      Frequently Asked Questions

      What is homocysteine?

      Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

      What does “bioavailable” mean?

      When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

      Read More

      Directions

      Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

      Warning

      Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician. Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

      Updated Jan 15, 2026
      Read More

      Supplement Facts

      Serving Size: 1 Tablet
      Number of Servings: 30 Servings
      Amount Per Serving
      % Daily Value
      FOLATE  - AS (6S)-5-METHYLTETRAHYDROFOLATE, CALCIUM SALT
      8,500 MCG
      2125%

      Other Ingredients:

      Microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.

      How Do You Read A Supplement Facts Label?

      Specifications

      Brand:
      Life Extension
      Form:
      Vegetarian Tablets
      Strength:
      8500 MCG
      Serving Size:
      1 Tablet
      Number of Servings:
      30 Servings
      Price per Serving:
      ($0.63 / serving)
      Product Weight:
      1  OZ
      Specialty Diets:
      Gluten Free ,  Non-GMO
      Item # :
      UX-13095 / 2295632

      Product Reviews
         (162)

      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

      162 Ratings
      4.7out of 5 stars
      162 Ratings

      Rated 5 stars by 84% of reviewers

      584%

      Rated 4 stars by 9% of reviewers

      49%

      Rated 3 stars by 5% of reviewers

      35%

      Rated 2 stars by 2% of reviewers

      22%

      Rated 1 star by 1% of reviewers

      11%
      Would you recommend?
      1-10 of 162 Reviews
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      • (136)
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      • 25-34 (0)
      • 35-44 (0)
      • 45-54 (0)
      • 55-64 (2)
      • 65+ (0)
      Customers talk about
      AI analysis found these key themes mentioned in reviews.
      Sep 2, 2026
      Rated 5 out of 5
      Works well
      easy swallow
      Mss
      Location
      Johnstown PA
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Mss has been flagged
      Flag
      Jul 5, 2026
      Rated 5 out of 5
      Good quality
      Peace of mind product.
      Teresa
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Teresa has been flagged
      Flag
      Jun 5, 2026
      Rated 5 out of 5
      Awesome Product
      I love this product
      Marie
      Location
      Johnstown PA
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Marie has been flagged
      Flag
      Apr 26, 2026
      Rated 4 out of 5
      Got just what I ordered
      Timely shipping and accurate order
      REBECCA
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by REBECCA has been flagged
      Flag
      Oct 13, 2025
      Rated 5 out of 5
      TMG
      Awesome
      Sabrina BVerified Purchaser
      Location
      Dover, TN, US
      Gender
      Female
      Age Range
      55-64
      Purchased on Sep 28, 2025
      Was this helpful?
      Review by Sabrina B has been flagged
      Flag
      Sep 26, 2025
      Rated 5 out of 5
      Best on the market
      Best Folate supplement available at a great price.
      MICHELINE
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by MICHELINE has been flagged
      Flag
      Jul 29, 2025
      Rated 5 out of 5
      This helps calm my busy mind at night
      I learned this trick from Dr. Paul Saladino to take L-Methylfolate at night if you have genetic variants in the MTHFR and COMT. I often have issues with "wide awake" brain at bedtime as I'm not good at breaking down catecholamines including dopamine. This has been helping me sleep better immensely!!
      KULIE
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by KULIE has been flagged
      Flag
      Jun 25, 2025
      Rated 5 out of 5
      Good place to get health supplements
      Easiest way to get a supplement that he needs. Quick service and fast shipping
      REBECCA
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by REBECCA has been flagged
      Flag
      Jun 18, 2025
      Rated 3 out of 5
      It must be okay, because I'm not feeling worse.
      I'm mostly anti-supplement except for medical reasons (i.e., a diagnosed deficiency or genetic metabolic issue) because I'm a big skeptic: I need peer-reviewed, repeatible studies. So I can only go off of this: I have an MTHFR gene issue of "moderate severity" via the test my psychiatrist had done for me, which is supposed to predict how well your body can metabolize antidepressants and such. I was told to take exactly this supplement, and I'm glad I was pointed here because it seems to be a…
      Satisfied Skeptic
      Location
      Wisconsin
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Satisfied Skeptic has been flagged
      Flag
      May 24, 2025
      Rated 5 out of 5
      Highly recommended
      Excellent supplement. I'm a regular buyer
      Marcos
      Location
      Undisclosed
      Would you recommend?:Yes
      Originally posted at Life Extension
      Was this helpful?
      Review by Marcos has been flagged
      Flag
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      Disclaimer:

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      1 Question
      Why did you choose this?
      The Vitamin ShoppeStore

      I have an autoimmune disorder and this really helps in suppressing it

      MICHAEL CSep 2, 2026

      Helps rebuild damaged cells

      Ronald BJun 21, 2026

      Doc recommended ha.

      Juan mJun 5, 2026

      Dr recommended based on patient’s results

      Laura HApr 30, 2026
      Questions for Similar Products
      Is this similar to metanx prescription vitamin?
      Optimized Folate L-Methylfolate
      About
      Optimized Folate L-Methylfolate
      A shopperSep 8, 2015

        L-methylfolate is one of about 4 or 5 ingredients in metanx. Metanx also has the non cyanide bound form of B12 and has calcium in it. These ingredients together are thought to help neuropathy in diabetics.

      Melody DAug 5, 2017purchased Jan 20, 2016
      Reply
      Inaccurate
      Answer by Melody D has been flagged

        We take this instead of Folic Acid. I recommend asking your pharmacist.

      Rebecca ASep 8, 2015purchased Apr 7, 2015
      Reply
      Inaccurate
      Answer by Rebecca A has been flagged

        I don't know. The doctor recommended to take other than multiple vit

      Linda BSep 8, 2015purchased Jul 17, 2014
      Reply
      Inaccurate
      Answer by Linda B has been flagged

        I am not sure what metanx prescription vitamin is.

      Elizabeth WSep 8, 2015purchased Jul 2, 2014
      Reply
      Inaccurate
      Answer by Elizabeth W has been flagged

      Vote for the best answer above!

      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

      Shipping Info

       

      FREE STANDARD SHIPPING on orders of $45 or more

      How to get FREE Standard Shipping:

      1. Ship to an address within the United States (including U.S. territories)
      2. Place your online order of $45 or more* - after promotions and before tax are applied
      3. Use "Standard" shipping option at checkout

      Orders will be shipped within 24 hours of order placement*, pending verification of billing information and shipping method selected. International orders and orders containing gift cards or items that are not currently in stock will be processed as quickly as possible.

       

      *Excludes all orders placed on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day).

       

      Orders for states outside of the continental U.S. (including those of $45 or more) may be subject to a delivery surcharge. This will be noted in the order summary based on your shipping address at checkout.

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      HomeVitamins & SupplementsLetter VitaminsVitamin BHigh Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

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      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.