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High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

$18.99
($0.63/serving)

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High Potency Optimized Folate – L-Methylfolate – 8,500 MCG Folic Acid (30 Tablets)

Rated 4.7 out of 5
162 Reviews2 Questions14 Answers
Gluten FreeNon-GMO
$18.99
($0.63/serving)

AUTO DELIVERY SAVE 15%

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Arrives Oct 31-Nov 1 to 20147
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Sterling, VAOpens 9:30 AM
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Product Info

About This Product

  • Supports cardiovascular and brain health
  • Helps maintain healthy homocysteine levels
  • Provides 8,500mcg of 5-MTHF per serving
  • Non-GMO and gluten-free

High Potency Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This potent formula features a high 8,500mcg dose of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

Frequently Asked Questions

What is homocysteine?

Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

What does “bioavailable” mean?

When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

Read More

Directions

Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

Warning

Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician. Keep out of reach of children. Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Read More

Supplement Facts

Serving Size: 1 Tablet
Number of Servings: 30 Servings
Amount Per Serving
% Daily Value
FOLATE  - AS (6S)-5-METHYLTETRAHYDROFOLATE, CALCIUM SALT
2125%

Other Ingredients:

Microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.

Specifications

Brand:
Life Extension
Form:
Vegetarian Tablets
Strength:
8500 MCG
Serving Size:
1 Tablet
Number of Servings:
30 Servings
Price per Serving:
($0.63 / serving)
Product Weight:
1  OZ
Specialty Diets:
Gluten Free ,  Non-GMO
Item # :
UX-13095 / 2295632

Product Reviews
   (162)

162 Ratings
4.7out of 5 stars
162 Ratings

Rated 5 stars by 84% of reviewers

Rated 4 stars by 9% of reviewers

Rated 3 stars by 5% of reviewers

Rated 2 stars by 2% of reviewers

Rated 1 star by 1% of reviewers

Would you recommend?
Customers review summary

The Life Extension L-Methyl-Folate supplement appeals to customers managing MTHFR variants or prenatal folate needs. Many customers appreciate its methylated form for reliable absorption, its ability to lower homocysteine and support energy, mood and healthy pregnancy outcomes, and the trust they place in Life Extension's formulation. A few customers note chalky texture, swallowing difficulty or oversized bottles, yet most report measurable health improvements that make it worth taking.

AI generated from customer reviews

1-10 of 162 Reviews
Customers talk about
Sep 2, 2026
Rated 5 out of 5
Works well
easy swallow
Mss
Location
Johnstown PA
Would you recommend?Yes
Was this helpful?
Jul 5, 2026
Rated 5 out of 5
Good quality
Peace of mind product.
Teresa
Location
Undisclosed
Would you recommend?Yes
Was this helpful?
Jun 5, 2026
Rated 5 out of 5
Awesome Product
I love this product
Marie
Location
Johnstown PA
Would you recommend?Yes
Was this helpful?
Apr 26, 2026
Rated 4 out of 5
Got just what I ordered
Timely shipping and accurate order
REBECCA
Location
Undisclosed
Would you recommend?Yes
Was this helpful?
Oct 13, 2025
Rated 5 out of 5
TMG
Awesome
Sabrina BVerified Purchaser
Location
Dover, TN, US
Gender
Female
Age Range
55-64
Purchased on Sep 28, 2025
Was this helpful?
Sep 26, 2025
Rated 5 out of 5
Best on the market
Best Folate supplement available at a great price.
MICHELINE
Location
Undisclosed
Would you recommend?Yes
Was this helpful?
Jul 29, 2025
Rated 5 out of 5
This helps calm my busy mind at night
I learned this trick from Dr. Paul Saladino to take L-Methylfolate at night if you have genetic variants in the MTHFR and COMT. I often have issues with "wide awake" brain at bedtime as I'm not good at breaking down catecholamines including dopamine. This has been helping me sleep better immensely!!
KULIE
Location
Undisclosed
Would you recommend?Yes
Was this helpful?
Jun 25, 2025
Rated 5 out of 5
Good place to get health supplements
Easiest way to get a supplement that he needs. Quick service and fast shipping
REBECCA
Location
Undisclosed
Would you recommend?Yes
Was this helpful?
Jun 18, 2025
Rated 3 out of 5
It must be okay, because I'm not feeling worse.
I'm mostly anti-supplement except for medical reasons (i.e., a diagnosed deficiency or genetic metabolic issue) because I'm a big skeptic: I need peer-reviewed, repeatible studies. So I can only go off of this: I have an MTHFR gene issue of "moderate severity" via the test my psychiatrist had done for me, which is supposed to predict how well your body can metabolize antidepressants and such. I was told to take exactly this supplement, and I'm glad I was pointed here because it seems to be a…
Satisfied Skeptic
Location
Wisconsin
Would you recommend?Yes
Was this helpful?
May 24, 2025
Rated 5 out of 5
Highly recommended
Excellent supplement. I'm a regular buyer
Marcos
Location
Undisclosed
Would you recommend?Yes
Was this helpful?
Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

Q&A

We'll email them your question, then email you their replies.

Have a question? Ask owners.Have a question about this? Ask people who own it.
Start typing and see existing answers.
1 Question
Why did you choose this?
The Vitamin ShoppeStore

I have an autoimmune disorder and this really helps in suppressing it

MICHAEL C

Helps rebuild damaged cells

Ronald B

Doc recommended ha.

Juan m

Dr recommended based on patient’s results

Laura H
Questions for Similar Products
Is this similar to metanx prescription vitamin?
Optimized Folate L-Methylfolate
About
Optimized Folate L-Methylfolate
A shopper

  L-methylfolate is one of about 4 or 5 ingredients in metanx. Metanx also has the non cyanide bound form of B12 and has calcium in it. These ingredients together are thought to help neuropathy in diabetics.

Melody D

  We take this instead of Folic Acid. I recommend asking your pharmacist.

Rebecca A

  I don't know. The doctor recommended to take other than multiple vit

Linda B

  I am not sure what metanx prescription vitamin is.

Elizabeth W

Vote for the best answer above!

Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

Shipping Info

 

FREE STANDARD SHIPPING on orders of $45 or more

How to get FREE Standard Shipping:

  1. Ship to an address within the United States (including U.S. territories)
  2. Place your online order of $45 or more* - after promotions and before tax are applied
  3. Use "Standard" shipping option at checkout

Orders will be shipped within 24 hours of order placement*, pending verification of billing information and shipping method selected. International orders and orders containing gift cards or items that are not currently in stock will be processed as quickly as possible.

 

*Excludes all orders placed on major US holidays (Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year's Day).

 

Orders for states outside of the continental U.S. (including those of $45 or more) may be subject to a delivery surcharge. This will be noted in the order summary based on your shipping address at checkout.

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    Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This formula features 1,700mcg of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

    Frequently Asked Questions

    What is homocysteine?

    Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

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