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SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 200 MG (50 Tablets)

Rated 4.3 out of 5
4 Reviews|7 Questions | 105 Answers|
The Vitamin Shoppe SAMe 200 MG tablets bottle front
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      Gluten FreeDairy FreeSugar FreeSoy FreeWheat Free
      GET ADVICE FROM A HEALTH ENTHUSIAST
      $29.99
      ($1.19/serving)

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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      These products are dietary supplements and are not intended to diagnose, treat cure or prevent any disease. Reviews are not intended as a substitute for appropriate medical care or the advice of a physician or another medical professional. Actual results may vary among users. Vitaminshoppe.com makes no warranty or representation, expressed or implied, as to the accuracy or validity of the information contributed by outside product review submissions, and assumes no responsibility or liability regarding the use of such information. The information and statements regarding the dietary supplements have not been evaluated by the Food and Drug Administration. If you have a medical condition or disease, please talk to your health care provider. If you are currently taking a prescription medication, you should work with your health care provider before discontinuing any drug or altering any drug regimen, including augmenting your regimen with dietary supplements. Do not attempt to self-diagnose any disease or ailment based on the reviews and do not use the information contained herein for diagnosing or treating a health problem or disease. Proper medical care is critical to good health. If you have a health concern or suspect you have an undiagnosed sign or symptom, please consult a physician or health care practitioner. Online product reviews are a useful resource for, but The Vitamin Shoppe believes that customers who rely on those reviews should get a true and accurate picture of what other customers think. For that reason, we put procedures in place to ensure the reviews you see are real and honest. Additionally, we won't edit reviews to alter the message and we will always treat positive and negative reviews equally.
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      SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 200 MG (50 Tablets)
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      Product Info

      About This Product

      • Provides mood support
      • Supports joint and liver health
      • Free of gluten, dairy, soy, and nuts

      The Vitamin Shoppe® brand SAM-e tablets are perfect for when your mood needs a little support. S-adenosylmethionine (SAM-e) is a compound involved in the production of serotonin and dopamine—AKA our feel-good hormones. Studies show that SAM-e can also promote joint and liver health.

      Add this supplement to your routine to support a positive mood, flexible joints, and a healthy liver.

      Frequently Asked Questions

      What is an enteric coating?

      An enteric coating protects the supplement from the harsh, acidic environment of the stomach. It allows the supplement to release once it passes through the stomach for optimal absorption.

      Read More

      Directions

      As a dietary supplement, take one (1) tablet twice per day on an empty stomach, or as directed by your physician.

      Warning

      Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions. KEEP OUT OF REACH OF CHILDREN.

      Updated Jan 15, 2026
      Read More

      Supplement Facts

      Serving Size: 2 Tablets
      Number of Servings: 25 Servings
      Amount Per Serving
      % Daily Value
      S-ADENOSYL-L-METHIONINE (SAM-E)  - (AS S-ADENOSYL-L-METHIONINEDISULFATE P-TOLUNENESULFONATE)
      200 MG
      N/A*

      Other Ingredients:

      Cellulose, silica, magnesium stearate, riboflavin, ethyl cellulose, oleic acid, medium chain triglycerides, sodium alginate, modified cellulose, triacetin, calcium carbonate, ammonium hydroxide.

      Does Not Contain:

      Preservative Free, Free of Artificial Flavors, Free of Animal Derivatives

      How Do You Read A Supplement Facts Label?

      Specifications

      Brand:
      The Vitamin Shoppe
      Form:
      Tablet(s)
      Strength:
      200 MG
      Serving Size:
      2 Tablets
      Number of Servings:
      25 Servings
      Price per Serving:
      ($1.20 / serving)
      Product Weight:
      5  OZ
      Allergens:
      Fish Free, Soy Free, Wheat Free
      Specialty Diets:
      Gluten Free ,  Dairy Free ,  Sugar Free ,  Yeast Free
      Item # :
      VS-1685 / 1299536

      Product Reviews
         (4)

      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

      4 Ratings
      4.3out of 5 stars
      4 Ratings

      Rated 5 stars by 75% of reviewers

      575%

      Rated 4 stars by 0% of reviewers

      40%

      Rated 3 stars by 0% of reviewers

      30%

      Rated 2 stars by 25% of reviewers

      225%

      Rated 1 star by 0% of reviewers

      10%
      4 Reviews
      • checkMost Recent
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      • Oldest
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      • Lowest Rated
      • (3)
      • (0)
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      • (1)
      • (0)
      • Under 18 (0)
      • 18-24 (1)
      • 25-34 (0)
      • 35-44 (0)
      • 45-54 (0)
      • 55-64 (0)
      • 65+ (0)
      Feb 19, 2024
      Rated 5 out of 5
      SAM-e
      ????
      Daisy BVerified Purchaser
      Location
      US
      Would you recommend?:Yes
      Purchased on Dec 11, 2023
      Was this helpful?
      Review by Daisy B has been flagged
      Flag
      Dec 4, 2022
      Rated 2 out of 5
      Not for me
      Made me jittery and irritable.
      Angie RVerified Purchaser
      Location
      Cumming, GA, US
      Purchased on Oct 27, 2022
      Was this helpful?
      Review by Angie R has been flagged
      Flag
      Jan 7, 2021
      Rated 5 out of 5
      Worth it!
      This is an excellent product. We have tried other brands and they are just not as effective! It may be little more expensive than some brands, but you get what you pay for!
      SHARIE BVerified Purchaser
      Location
      Plainfield, IN, US
      Gender
      Female
      Age Range
      18-24
      Would you recommend?:Yes
      Purchased on Nov 22, 2020
      Was this helpful?
      Review by SHARIE B has been flagged
      Flag
      Oct 10, 2010
      Rated 5 out of 5
      Same 200 Mg S-Adenosyl-L-Methionine
      great product!! I started taking this a couple of years ago and withing 10 days my knee felt significantly better. Now 2 years later and my knee feels better then it has in 30 years. I snow ski and all last season - no pain. My knee feels great every day!!!!!
      paul f
      Location
      Undisclosed
      Was this helpful?
      Review by paul f has been flagged
      Flag
      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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      7 Questions
      Most Recent Question
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      Oldest Answer
      Why did you choose this?
      The Vitamin ShoppeStore

      I am trying it for its potential benefit in joint support.

      samantha sJul 22, 2026

      Reformulation less likely to irritate my GI tract. Ran out of other options.

      Thomas WMay 9, 2026

      This was recommended by my Vet to help protect his liver from other medication’s that can be damaging.

      Elizabeth WMar 30, 2026

      Joint support

      Gary CMar 3, 2026
      Can this pill be cut in half?
      A shopperMar 15, 2014

      Best Answer:  We have the 400mg tablets and both are solid oval pills so they could be cut, but they are dense and hard without any score line, so it may not be easy.

      Leonhard KMar 15, 2014
      Reply
      Inaccurate
      Answer by Leonhard K has been flagged
      Just started using SAMe. Not sure if its a side effect or unrelated but, my gums are sore. Began almost immediately after first dose. Anyone else get this effect?
      thanks,
      Jean
      jean bJun 27, 2013

      Best Answer:  Sorry about your gum issue. We didn't have that experience but since my husband has been taking it for the past year and a half, he has not had any recurrence of kidney stones or gout. Wishing you good luck with this treatment,
      Margaret

      margaret mJun 28, 2013
      Reply
      Inaccurate
      Answer by margaret m has been flagged
      Does this product have Mannitol? I heard Mannitol can make the product hurt the stomach
      ColleenMay 25, 2021

      Best Answer:  I have a tricky stomach and have not experienced trouble from using this product. These are the listed ingredients:
      Cellulose, silica, magnesium stearate, riboflavin, ethyl cellulose, oleic acid, medium chain triglycerides, sodium alginate, modified cellulose, triacetin, calcium carbonate, ammonium hydroxide.

      Jessica KMay 25, 2021purchased Sep 19, 2020
      Reply
      Inaccurate
      Answer by Jessica K has been flagged
      How big are these tablets, please? Are they hard to swallow?
      Lisa KSep 18, 2021

      Best Answer:  They are round yellow and 3/8 an inch diameter. Easy to swallow, I can’t even feel them going down with water.

      KathySep 18, 2021purchased Jan 20, 2019
      Reply
      Inaccurate
      Answer by Kathy has been flagged
      Are these pills enteric coated?
      Jenn I.Mar 28, 2022

      Best Answer:  I think so....maybe call the VS to make sure.

      Noela EMar 28, 2022purchased Oct 22, 2019
      Reply
      Inaccurate
      Answer by Noela E has been flagged

      I just saw it was listed on the bottle...my mistake. Thank you!

      Jenn I.Mar 29, 2022
      Reply

      👍🏼😊

      Noela EMar 29, 2022
      Reply
      Terry C. said she was using it for her dog's liver. How did it work for your dog?
      Lorrie CAug 29, 2019

      Best Answer:  I never heard of such a thing-I use it for mild depression and joint pain

      Susan SAug 29, 2019purchased Dec 17, 2017
      Reply
      Inaccurate
      Answer by Susan S has been flagged
      Disclaimer:

      Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

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      HomeHerbs & Natural RemediesShop By ConcernSleep & MoodSAM-e - Enteric Coated - Mood, Joint, & Liver Support - 200 MG (50 Tablets)

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      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×

      AUTO DELIVERY
      Auto Delivery is the best way to put your wellness goals first—and enjoy huge savings every time! We’ll send your essentials at a pace you choose (switch it up any time).
      • Forever Savings: You’ll get 20% off The Vitamin Shoppe® and Vthrive The Vitamin Shoppe® brands, 15% off everything else. Every subscription order. Every time.
      • Never Run Out: Stay effortlessly stocked up with your essentials.
      • Easily Manage: Use our app to easily manage subscriptions.
      • Free Shipping on Refills: Zero cost to replenish products of $25 or more.
      • View Auto Delivery FAQs for additional information
      Rely on the
      Vitamin Shoppe® 100% Satisfaction Guarantee
      Free shipping applies to Auto Delivery replenishment orders when the total value of all subscribed items exceeds $25 after discount is applied. Shipping surcharge may apply if delivered to Alaska or Hawaii.
      One-time coupon discounts don’t carry over to recurring orders.If a coupon offer is applied to purchase of multiple items (i.e. “Buy One, Get One 50% Off, Buy 2, Get 1 Free, etc...) and you select Auto Delivery, all items will be added as recurring orders.
      You may return any item purchased from the Vitamin Shoppe for any reason within thirty (30) days of purchase. For online and catalog orders, the product ship date is the date of purchase. Refunds for unopened items will be issued via your original form of payment with one exception. Online orders paid for with PayPal and returned to a Vitamin Shoppe retail store will be refunded via merchandise credit.
      ×
      By opting in to Notify Me alerts, you've consented to receiving marketing communications including information about the Healthy Awards® program.
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      Buy one, get one 50% off Private Brands products. Offer valid 08/24/2026 through 09/20/2026. Discount taken off price of second item of equal or lesser value. Excludes clearance items.