• Supports brain and liver health
• Promotes fat metabolism
• Suitable for everyday wellness seekers
• Free of gluten, dairy, soy, nuts, sugar, salt, and preservatives

• Supports cardiovascular and brain health
• Helps maintain healthy homocysteine levels
• Non-GMO and gluten-free

Optimized Folate from Life Extension promotes cardiovascular and cognitive health by helping maintain healthy homocysteine levels—an important biomarker for both brain and heart wellness. This formula features 1,700mcg of 5-MTHF, the active, highly bioavailable form of folic acid, which helps reduce excess homocysteine.

Frequently Asked Questions

What is homocysteine?

Homocysteine is an amino acid that interacts with B vitamins and converts to methionine (a protein-building amino acid and antioxidant) and cysteine (an amino acid that supports liver health). Over time, homocysteine can accumulate in the bloodstream, potentially impacting cardiovascular health, cognitive function, and more.

What does “bioavailable” mean?

When something is bioavailable, it means that it’s more readily absorbed and used by the body. 

• Supports healthy hair, skin, and nails
• Promotes energy production
• Suitable for everyday wellness seekers
• Free of gluten, dairy, soy, nuts, sugar, salt, and artificial colors or flavors

• Promotes energy production
• Supports stress management
• Contains active co-enzyme forms of essential B vitamins
• Free of gluten, dairy, soy, and nuts

B vitamins play a key role in generating energy from the food we eat, as well as supporting brain function, nerve health, and a healthy stress response—but they’re not always easily absorbed by the body. Co-Enzyme B-Complex from The Vitamin Shoppe^® brand contains vitamins B1, B2, B5, B6, B12—plus choline and folate—in their active, most readily absorbed forms.