Naturally Derived SAMe 400

Jarrow Formulas® SAMe 400 provides a full 400 mg SAMe (net yield) from

800 mg of SAMe tosylate disulfate. SAMe 400 is manufactured under low

temperature and low humidity and is enteric-coated to ensure a biologically

active product.

With More of the Biologically Active S,S than R,S Form Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas® SAMe is made by microbiological fermentation and

processed without chemical solvents to preserve 68-80% (S,S) SAMe.

SAMe supports:

Brain Metabolism and Mood*

SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the

brain and cellular membranes.* It has also been proposed to be involved

in the formation or metabolism of neurotransmitters, which helps to support a balanced mood.*

Joint Health*

SAMe supports the production of healthy connective tissue through

transsulfuration.* In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including

glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage.*

Liver Function*

SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.*

Jarrow Formulas® QH-absorb® + PQQ™ combines Ubiquinol, the active antioxidant form of Co-Q10 that has been shown to be better absorbed, with PQQ, another antioxidant to promote mitochondrial biogenesis (the creation of new mitochondria).* QH-absorb + PQQ provides dual antioxidant support for mitochondrial health and healthy cardiovascular function, while also helping to restore Co-Q10 levels reduced by statins and/or aging*.