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Cleanse & Detox

Feeling sluggish or out of sync? A cleanse and detox routine may help support your body’s natural elimination processes and give you a fresh start. At The Vitamin Shoppe, we offer a wide range of cleanse and detox supplements—from full-body options to targeted formulas for the liver, kidneys, and digestive system.

  • Digestion & Gut Health
    • Cleanse & Detox
      • Liver Cleanse (23)
      • Detox Support (13)
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Liver Cleanse (23)
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  • Digestion & Gut Health
    • Cleanse & Detox
      • Liver Cleanse (23)
      • Detox Support (13)
      • Total Body Cleanse (8)
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Digestion & Gut Health
Cleanse & Detox
Liver Cleanse (23)
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Displaying 1 - 46 of 84
Dose for Your Liver – Supports Liver Health – Orange & Ginger (16 fl. oz./8 Servings)
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Dose
Dose for Your Liver – Supports Liver Health – Orange & Ginger (16 fl. oz./8 Servings)
(22)
$29.99
($3.75/Serving)

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Dose for Your Liver – Supports Liver Health – Orange & Ginger (12 Shots, 2 fl. oz. Each)
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Dose
Dose for Your Liver – Supports Liver Health – Orange & Ginger (12 Shots, 2 fl. oz. Each)
(22)
$54.99
($4.58/Serving)

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Mag O7 Ultimate Oxygenating Digestive System Cleanser (180 Vegetable Capsules)
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NB Pure
Mag O7 Ultimate Oxygenating Digestive System Cleanser (180 Vegetable Capsules)
(201)
$41.99
($0.70/Serving)

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Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 300 MG (200 Capsules)
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The Vitamin Shoppe
Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 300 MG (200 Capsules)
(49)
4 Strengths | More Sizes
$29.99
($0.15/Serving)

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Mega Clean Herbal Liquid Cleanse - Tropical Fruit (32 Fluid Ounces)
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Detoxify Llc
Mega Clean Herbal Liquid Cleanse - Tropical Fruit (32 Fluid Ounces)
(25)
$44.99
(/Serving)

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Kidney - Healthy Kidney Support (135 Capsules)
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Revive MD
Kidney - Healthy Kidney Support (135 Capsules)
(3)
$54.99
($1.22/Serving)

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Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 300 MG (100 Capsules)
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The Vitamin Shoppe
Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 300 MG (100 Capsules)
(49)
4 Strengths | More Sizes
$19.99
($0.20/Serving)

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How to Make Fibermaxxing Work for You: The Dos and Don'ts

Here's why jumping into this fiber-filled trend headfirst could be your next gut health power move.

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Liver Health Support Formula (120 Vegetarian Capsules)
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Revive MD
Liver Health Support Formula (120 Vegetarian Capsules)
(2)
$54.99
($1.83/Serving)

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Mag O7 Ultimate Oxygenating Digestive System Cleanser (90 Vegetable Capsules)
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NB Pure
Mag O7 Ultimate Oxygenating Digestive System Cleanser (90 Vegetable Capsules)
(201)
$27.99
($0.93/Serving)

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QCarbo32 with Eliminex Plus - 1 Step Maximum Strength Liquid Cleansing Formula - Tropical (32 Fluid Ounces)
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Herbal Clean
QCarbo32 with Eliminex Plus - 1 Step Maximum Strength Liquid Cleansing Formula - Tropical (32 Fluid Ounces)
(8)
2 Flavors | More Sizes
$43.30 $51.99
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Ready Clean Herbal Liquid Cleanse - Detox Drink with Vitamins & Minerals - Tropical Fruit (16 Fluid Ounces)
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Detoxify Llc
Ready Clean Herbal Liquid Cleanse - Detox Drink with Vitamins & Minerals - Tropical Fruit (16 Fluid Ounces)
(15)
$24.99
($24.99/Serving)

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Super Colon Cleanse with Psyllium Husks, Senna Leaf, Acidophilus & Papaya (240 Capsules)
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Health Plus
Super Colon Cleanse with Psyllium Husks, Senna Leaf, Acidophilus & Papaya (240 Capsules)
(134)
$32.99
($0.27/Serving)

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Detoxification & Intestinal Purification Liquid #7 (32 Fluid Ounces)
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Sonnes Organic Foods
Detoxification & Intestinal Purification Liquid #7 (32 Fluid Ounces)
(34)
$32.99
($0.52/Serving)

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Milk Thistle for Liver Health - Full Spectrum Extract & Whole Seed (90 Capsules)
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plnt
Milk Thistle for Liver Health - Full Spectrum Extract & Whole Seed (90 Capsules)
(3)
$20.99
($0.23/Serving)

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Organic Milk Thistle Extract - Alcohol-Free - Antioxidant Support & Liver Health - 1,000 MG (2 fl. oz.)
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The Vitamin Shoppe
Organic Milk Thistle Extract - Alcohol-Free - Antioxidant Support & Liver Health - 1,000 MG (2 fl. oz.)
(18)
$12.99
($0.22/Serving)

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Liver Cleanse for Healthy Liver Function Support with Milk Thistle (60 Vegan Capsules)
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Gaia Herbs
Liver Cleanse for Healthy Liver Function Support with Milk Thistle (60 Vegan Capsules)
(56)
$34.97
($0.58/Serving)

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Milk Thistle Extract – Supports Liver Function – 80% Silymarin (60 Vegan Capsules)
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Nature's Way
Milk Thistle Extract – Supports Liver Function – 80% Silymarin (60 Vegan Capsules)
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$20.99
($0.35/Serving)

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The Cleaner - 7-Day Women's Formula - Ultimate Body Detox (52 Capsules)
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Century Systems
The Cleaner - 7-Day Women's Formula - Ultimate Body Detox (52 Capsules)
(198)
$19.99
($1.54/Serving)

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Liver Cleanse - Antioxidant to Support Liver Health (60 Vegetable Capsules)
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The Vitamin Shoppe
Liver Cleanse - Antioxidant to Support Liver Health (60 Vegetable Capsules)
(6)
$22.99
($0.77/Serving)

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Xxtra Clean Herbal Liquid Cleanse with Ginseng Extract - Tropical Fruit (20 Fluid Ounces)
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Detoxify Llc
Xxtra Clean Herbal Liquid Cleanse with Ginseng Extract - Tropical Fruit (20 Fluid Ounces)
(1)
$37.99
(/Serving)

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DIM Detox - Supports Detoxification & Cellular Health (60 Capsules)
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Pure Encapsulations
DIM Detox - Supports Detoxification & Cellular Health (60 Capsules)
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$58.99
($1.97/Serving)

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Ultra Eliminex Premium - 1 Step Maximum Strength Liquid Cleansing Formula - Strawberry Mango (32 Fluid Ounces)
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Herbal Clean
Ultra Eliminex Premium - 1 Step Maximum Strength Liquid Cleansing Formula - Strawberry Mango (32 Fluid Ounces)
(12)
2 Flavors | More Sizes
$82.99
($82.99/Serving)

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Liver Support – Herbal Formula with Milk Thistle & Oregon Grape (90 Vegetarian Capsules)
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plnt
Liver Support – Herbal Formula with Milk Thistle & Oregon Grape (90 Vegetarian Capsules)
(3)
$24.99
($0.28/Serving)

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The Cleaner - 14-Day Women's Formula - Ultimate Body Detox (104 Capsules)
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Century Systems
The Cleaner - 14-Day Women's Formula - Ultimate Body Detox (104 Capsules)
(28)
$30.99 $34.99
(11% off)

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The Cleaner - 7-Day Men's Formula - Ultimate Body Detox (52 Capsules)
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Century Systems
The Cleaner - 7-Day Men's Formula - Ultimate Body Detox (52 Capsules)
(32)
$19.99
($1.54/Serving)

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Liver Detox with Turmeric Root, Milk Thistle, NAC & Alpha Lipoic Acid - 620 MG (60 Capsules)
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Health Plus
Liver Detox with Turmeric Root, Milk Thistle, NAC & Alpha Lipoic Acid - 620 MG (60 Capsules)
(15)
$32.99
($1.10/Serving)

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Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 175 MG (300 Capsules)
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The Vitamin Shoppe
Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 175 MG (300 Capsules)
(49)
4 Strengths | More Sizes
$39.99
($0.13/Serving)

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Cleanse More - Overnight Formula for Occasional Constipation (60 Capsules)
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Renew Life
Cleanse More - Overnight Formula for Occasional Constipation (60 Capsules)
(80)
$20.99
($0.70/Serving)

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Cleanse More Herbal Formula with Magnesium (100 Vegan Capsules)
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Renew Life
Cleanse More Herbal Formula with Magnesium (100 Vegan Capsules)
(80)
$37.99
($0.76/Serving)

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The Cleaner - 14-Day Men's Formula - Ultimate Body Detox (104 Capsules)
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Century Systems
The Cleaner - 14-Day Men's Formula - Ultimate Body Detox (104 Capsules)
(8)
$34.99
($1.35/Serving)

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Liver Detox & Blood Refresh - 540mg Milk Thistle Extract (60 Liquid Softgels)
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Irwin Naturals
Liver Detox & Blood Refresh - 540mg Milk Thistle Extract (60 Liquid Softgels)
(1)
$23.99 $29.99
(20% off)

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Puri-T for Liver Support with Milk Thistle & NAC (60 Vegetarian Capsules)
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Life Seasons
Puri-T for Liver Support with Milk Thistle & NAC (60 Vegetarian Capsules)
(28)
$34.99
($1.17/Serving)

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Milk Thistle - Full Potency Herb (100 Vegetarian Capsules)
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Solgar
Milk Thistle - Full Potency Herb (100 Vegetarian Capsules)
(3)
$25.99
($0.26/Serving)

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Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 70 MG (100 Capsules)
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The Vitamin Shoppe
Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 70 MG (100 Capsules)
(49)
4 Strengths | More Sizes
$12.99
($0.13/Serving)

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Kidney Health Formula - Supports Kidney Function & Overall Health (60 Capsules)
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PureHealth Research
Kidney Health Formula - Supports Kidney Function & Overall Health (60 Capsules)
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$22.48 $44.97
(50% off)

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Super Cleanse - Extra Strength Formula with 13 Cleansing Herbs & Fibers (200 Tablets)
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Natures Secret
Super Cleanse - Extra Strength Formula with 13 Cleansing Herbs & Fibers (200 Tablets)
(58)
$27.19 $33.99
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Kidney Cleanse with Cranberry, Buchu Leaf, Turmeric & CoQ-10 - 550 MG (60 Capsules)
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Health Plus
Kidney Cleanse with Cranberry, Buchu Leaf, Turmeric & CoQ-10 - 550 MG (60 Capsules)
(7)
$27.99
($0.93/Serving)

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Kidney Health & Detoxification Support with Uva Ursi & Cranberry (60 Capsules)
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Snap Supplements
Kidney Health & Detoxification Support with Uva Ursi & Cranberry (60 Capsules)
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$39.99
($1.33/Serving)

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Milk Thistle Triple Detox , GLP-1 Detox Aid (60 Liquid Soft Gels)
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Irwin Naturals
Milk Thistle Triple Detox , GLP-1 Detox Aid (60 Liquid Soft Gels)
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$27.19 $33.99
(20% off)

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Ultra Eliminex Premium - 1 Step Maximum Strength Liquid Cleansing Formula - Tropical (32 Fluid Ounces)
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Herbal Clean
Ultra Eliminex Premium - 1 Step Maximum Strength Liquid Cleansing Formula - Tropical (32 Fluid Ounces)
(12)
2 Flavors | More Sizes
$82.99
($82.99/Serving)

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Milk Thistle Liver Detox with Dandelion, Artichoke & Beet Green (60 Softgels)
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Irwin Naturals
Milk Thistle Liver Detox with Dandelion, Artichoke & Beet Green (60 Softgels)
(1)
$23.99 $29.99
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Milk Thistle - Super Concentrated & Alcohol Free - 2,000 MG Per Serving (1 fl oz)
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Natures Answer
Milk Thistle - Super Concentrated & Alcohol Free - 2,000 MG Per Serving (1 fl oz)
(5)
$17.99
($1.20/Serving)

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Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 175 MG (100 Capsules)
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The Vitamin Shoppe
Milk Thistle Extract - Promotes Liver Health & Antioxidant Support - 175 MG (100 Capsules)
(49)
4 Strengths | More Sizes
$17.99
($0.18/Serving)

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Milk Thistle for Liver Health Support - 300 MG (100 Capsules)
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Force Factor
Milk Thistle for Liver Health Support - 300 MG (100 Capsules)
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$21.99
($0.22/Serving)

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Organic Triphala - Digestion & Colon Cleanse blend of Amla, Bibhitaki and Haritaki (90 Vegetarian Capsules)
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Organic India USA
Organic Triphala - Digestion & Colon Cleanse blend of Amla, Bibhitaki and Haritaki (90 Vegetarian Capsules)
(50)
$18.39 $22.99
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Liver-G.I. Detox - Supports Liver & Gastrointestinal Detoxification (60 Capsules)
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Pure Encapsulations
Liver-G.I. Detox - Supports Liver & Gastrointestinal Detoxification (60 Capsules)
(2)
$35.99
($1.20/Serving)

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    • Promotes Healthy Liver Functions
    • Holistically Balanced®
    • Natures Answer® alcohol-free extracts are produced using alcohol, water and natural extractants. All alcohol and extractants are then removed through our cold Bio-Chelated® proprietary extraction process, yielding a Holistically Balanced® standardized extract. Liquid extracts are absorbed faster then tablets or capsules, and are more potentthen tinctures. Holistically Balanced® guarantees that the constituents of the extract are in the same synergistic ratios as in the plant. Manufactured in our FDA ® and pharmaceutically licensed facility; Unconditionally guaranteed.
    Rated 4 stars out of 5 stars, From 5 customer reviews (5)
    $17.99
    Add To Cart Quick View >
  • Herbal Detoxify Formula
    Lily Of The Desert
    Aloe Herbal Detox Formula - Daily Detox with Whole Leaf & Inner Fillet Aloe (32 Fluid Ounces)
    Aloe Herbal Detox Formula - Daily Detox with

    Daily detoxifying formula. Enhanced with polysaccharide-rich. Made with filtered whole leaf and inner fillet aloe vera. Clinically proven to reduce cell nitrate by 11%.

    Aloesorb - High molecular-weight naturally occurring aloe polysaccharides that have been infused back into the product. Clinically proven to improve absorption, immune support and reduction of nitrate levels.

    Burdock Root - Helps with ailments and complaints of the gastrointestinal tract as a diaphoretic and diuretic, and supports blood purification.

    Acacia Gum - Assists in the development of the beneficial bacterias, bifid bacteria and lactobacilli. Leads to the production of short chain fatty acids, which play numerous beneficial roles in the physiology of the human body.

    Milk Thistle - Promotes decreased production of superoxide anion radicals and nitric acid. Supports production of glutathione by the liver, intestines and stomach. Glutathione is used for detoxification of cells in the liver.

    Dandelion Leaf - Boosts support of healthy liver and gallbladder function and inflammatory conditions of the efferent urinary tract.

    Slippery Elm Bark - Eases inflammation and further cleansing of waste from the colon.

    Lily of the Desert Aloe Vera Benefits:

    -Contains full range of valuable aloe polysaccharides.

    -Clinically proven to increase absorption of other supplements when taken with aloe vera juice.

    -Helps restore and promote regularity.

    -Helps support a healthy digestive system.

    -Helps maintain stomach pH balance.

    Aloesorb: naturally occurring high molecular weight aloe polysaccharides that have been isolateed through a patented process and infused back into our aloe juices. Lily has completed a series of clinical studies on our own aloe juice with Aloesorb, and these studies shoe:

    -A 20-fold increase in absorption of Vitamin C vs. when taken with water.

    -Improved immune support by a 16% increase in white blood cells.

    -Improved antioxidant support by over 40%.

    Rated 5 stars out of 5 stars, From 4 customer reviews (4)
    $21.97
    Add To Cart Quick View >
  • 2-in-1 Cleanse & Flush Weight Loss Support
    Irwin Naturals
    2-in-1 Cleanse & Flush - Supports Weight Loss & Reduces Excess Water Weight (60 Softgels)
    2-in-1 Cleanse & Flush - Supports Weight Loss

    Irwin Naturals 2-in-1 Cleanse and Flush Weight Loss Support

    • Flush up to 2-to-3 Pounds of Backed-Up Matter
    • Reduce Excess Water Weight
    • Plus Gymnema Extract
    Rated 3 stars out of 5 stars, From 8 customer reviews (8)
    $26.95
    Add To Cart Quick View >
  • Qcarbo16 - Grape
    Herbal Clean
    QCarbo16 with Eliminex Plus - Mega Strength Liquid Cleansing Formula - Grape (16 Fluid Ounces)
    QCarbo16 with Eliminex Plus - Mega Strength Liquid
    • HERBAL CLEAN QCARBO16
    • WITH ELIMINEX HERBAL SUPPLEMENT
    • MEGA STRENGTH CLEANSING FORMULA

    HERBAL CLEAN QCARBO16 is designed to provide the MEGA STRENGTH necessary to blast through your body and help cleanse excessive toxin build up. One of the most popular detox products on the market, it proves time and time again to be a reliable potent cleanser.

    Today's lifestyles expose us to numerous pollutants from many sources including the air we inhale, water we drink and food we ingest. It is important to eliminate these toxins safely and with peace of mind. QCARBO16 confidently provides reliability and satisfaction for your cleansing needs and improved lifestyle.

    Rated 4 stars out of 5 stars, From 6 customer reviews (6)
    $39.99
    Add To Cart Quick View >
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What is a cleanse and detox?

A cleanse and detox typically refers to a regimen aimed at supporting the body’s natural ability to eliminate waste and toxins through organs like the liver, kidneys, and colon. While your body already has built-in detoxification systems, certain supplements and herbs may help support these processes—especially when paired with a healthy diet and lifestyle.

Whether you're looking for a natural cleanse and detox after a period of indulgence or want to maintain regularity and organ health, our selection includes capsules, liquids, teas, powders, and more to help you feel refreshed and rebalanced.

What are the potential benefits of a cleanse or detox?

Goals of a detox and cleanse may include:

  • Supporting liver and kidney function
  • Promoting digestive regularity
  • Encouraging healthy skin and energy levels
  • Supporting immune health and metabolic balance

Some formulas target specific organs or systems of the body, so the potential benefits can vary by product.

Targeted detox & cleanse supplements

The Vitamin Shoppe carries top body cleanse options, from complete regimens to natural detox support supplements. Explore a variety of cleanse and detox body solutions tailored to your needs.

  • Total-body detox: Convenient all-in-one programs ranging from 3-day resets to month-long cleanses. These kits often include herbal blends designed to gently support elimination and organ health.
  • Liver cleanse and detox: Supplements that may support liver function, one of the body’s primary detox organs.
  • Kidney cleanse and detox: Formulas designed to promote urinary tract health and help the kidneys filter waste.
  • Colon cleanse and detox: Products that may support digestive regularity and intestinal health.
  • Detox teas: Herbal blends that may support kidney, liver, and blood health while offering a soothing daily ritual.

What are the best cleanse detox brands?

The Vitamin Shoppe carries many name brands, including these top labels: The Vitamin Shoppe, Detoxify, Herbal Clean, Health Plus, and Renew Life.

Shop Cleanse & Detox at The Vitamin Shoppe

Ready to reset and recharge? Whether you're starting a full body cleanse and detox, liver and kidney cleanse detox, or simply want to support your body's natural processes, we have the products to help you feel your best. Browse our full selection online or visit your local Vitamin Shoppe store for everything you need to support your wellness journey.

Find Cleanse & Detox at The Vitamin Shoppe Store Near You

There are more than 600 The Vitamin Shoppe® stores across the US, so it's very likely you can pop in and find Cleanse & Detox locally. Check out our store locator to find a Shoppe near you. Don’t forget—you’ll save at least 15% on every subscription with Auto Delivery, plus an addition 5% off select brands to help you stay on the path. Not only will you never miss a thing, but you’ll also get free shipping on subscription refills of $25 or more!* You define what better looks (and feels) like—Count on us to help you get there.


Shipping & Returns

  • FREE for Orders over $45

    Orders under $45, domestic shipping is only $7.99. Find more at our Shipping Policy page.

  • Return Policy for Items Purchased Online

    Shop with confidence with our Easy Returns Policy. Customers may return any opened or unopened merchandise purchased from any Vitamin Shoppe channel to any Vitamin Shoppe store within 30 days. Find more at our full Returns Policy page.

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