SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 400 MG (60 Tablets)

Name: SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 400 MG (60 Tablets)
Brand: The Vitamin Shoppe
SKU: VS-2659
Price: 49.99 USD
Availability: OutOfStock
Rating: 4.9 (16 reviews)

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SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 400 MG (60 Tablets)

Gluten FreeDairy FreeSugar FreeSoy FreeWheat Free

GET ADVICE FROM A HEALTH ENTHUSIAST

Strength

400 MG

Size

60 Tablet(S)$49.99

Delivery Options

Shipping

Temporarily Out of Stock

Pick-Up

Sterling, VA

Available in nearby stores

Same-Day

Temporarily Out of Stock

to 20147

Product Info

About This Product

Provides mood support
Supports joint and liver health
Free of gluten, dairy, soy, and nuts

The Vitamin Shoppe^® brand SAM-e tablets are perfect for when your mood needs a little support. S-adenosylmethionine (SAM-e) is a compound involved in the production of serotonin and dopamine—AKA our feel-good hormones. Studies show that SAM-e can also promote joint and liver health.

Add this supplement to your routine to support a positive mood, flexible joints, and a healthy liver.

Frequently Asked Questions

What is an enteric coating?

An enteric coating protects the supplement from the harsh, acidic environment of the stomach. It allows the supplement to release once it passes through the stomach for optimal absorption.

Directions

As a dietary supplement, take one (1) tablet per day on an empty stomach, or as directed by your physician.

Warning

Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions. KEEP OUT OF REACH OF CHILDREN.

Supplement Facts

Serving Size: 1 Tablet

Number of Servings: 60 Servings

Amount Per Serving

% Daily Value

S-ADENOSYL-L-METHIONINE - (SAM-E) (AS S-ADENOSYL-L-METHIONINE TOSYLATE DISULFATE)

N/A*

Other Ingredients:

Cellulose, silica, magnesium stearate, riboflavin, ethyl cellulose, oleic acid, medium chain triglycerides, sodium alginate, modified cellulose, triacetin, calcium carbonate, ammonium hydroxide.

Does Not Contain:

Preservative Free, Free of Artificial Flavors, Free of Animal Derivatives

Specifications

Brand:

The Vitamin Shoppe

Form:

Tablet(s)

Strength:

400 MG

Serving Size:

1 Tablet

Number of Servings:

60 Servings

Price per Serving:

($0.83 / serving)

Product Weight:

8 OZ

Allergens:

Fish Free, Soy Free, Wheat Free

Specialty Diets:

Gluten Free , Dairy Free , Sugar Free , Yeast Free

Item # :

VS-2659 / 1721133

Product Reviews
(16)

16 Ratings

4.9out of 5 stars

16 Ratings

Rated 5 stars by 88% of reviewers

Rated 4 stars by 12% of reviewers

Rated 3 stars by 0% of reviewers

Rated 2 stars by 0% of reviewers

Rated 1 star by 0% of reviewers

Jun 29, 2023

Rated 5 out of 5

works well

no digestive issues caused by additives

SerenaVerified Purchaser

Would you recommend?:Yes

Purchased on May 14, 2021

Sep 17, 2021

Rated 5 out of 5

Only brands that works!

I?ve tried many other brands and Vitamin Shoppe brand is hands down the best. Works on mood stabilization and it a staple for me!

SHARIE BVerified Purchaser

Location

Plainfield, IN, US

Gender

Female

Age Range

18-24

Would you recommend?:Yes

Purchased on Jun 9, 2021

Jun 7, 2021

Rated 5 out of 5

Sam-e for my dog

I?m using this for my dog which has Valley Fever. He is currently on Fluconazole, Olive Leaf, Milk Thistle and Sam-e. He is doing much better with the regimen he is on.

TAMARA NVerified Purchaser

Location

Newbury Park, CA, US

Gender

Female

Age Range

55-64

Would you recommend?:Yes

Purchased on Apr 27, 2021

Aug 17, 2020

Rated 5 out of 5

Sam-e

Works as advertised and expected. Easy to take for me.

Brad JVerified Purchaser

Location

Queen Creek, AZ, US

Gender

Male

Age Range

55-64

Would you recommend?:Yes

Purchased on Jul 17, 2020

Jul 13, 2018

Rated 5 out of 5

SAM-e

I've been using SAM-e for several months and I truly believe it has helped me with my overall emotional well being

DEBBY BVerified Purchaser

Location

Beachwood, OH, US

Gender

Female

Age Range

65+

Would you recommend?:Yes

Purchased on Jun 28, 2018

Nov 13, 2015

Rated 4 out of 5

Sam E is amazing aa a mood enhancer!

Price a nd size of pills are both perfect.

Creacher

Location

Miami, Fla.

Would you recommend?:Yes

Feb 20, 2014

Rated 5 out of 5

Love It!

This product helps with my fibromyalgia pain and stiffness. It's easy to take and produces results.

Dee

Location

Acworth, GA

Would you recommend?:Yes

Dec 26, 2013

Rated 5 out of 5

Too high a price?

I could feel the difference when I did or didn't takemy Sam-E but in the store I was shocked at the price.I ran all over town when it was on a rare sale. The V-shop brand is affordable enough I can up my dose till the days lengthen again. No difference in quality.

Menopaused & SADD

Location

Greenville, SC

Would you recommend?:Yes

Nov 7, 2013

Rated 4 out of 5

SAMe

use as a nutritional suppliment

Jeff

Location

Falls Church, VA

Would you recommend?:Yes

Aug 28, 2013

Rated 5 out of 5

I hope it works!

I began taking this product over 15 years ago due to my inherited osteoarthritis and the pain it caused me on long runs. The mood improving effect may be responsible for most benefits, but the end result is that I could run and work out. I noticed the difference in my endurance and enthusiasm during times when I was without this supplement due to not being able to obtain it. I can't attribute any earth-shaking effects to this supplement, but it has been useful as a part of my total diet. during…

Road Doctor

Location

Maryland's Eastern Shore

Would you recommend?:Yes

Disclaimer:

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of the Vitamin Shoppe. Vitamin Shoppe does not verify or endorse any claims made in these reviews.Please read the full product reviews disclaimer.

Q&A

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Why did you choose this?

The Vitamin ShoppeStore

Mood and joint support

Greg PAug 22, 2026

Recommended

SHARON AJul 16, 2026

Ran out

Debra BJun 24, 2026

It helps with sleep and mood

SHARON AJun 23, 2026

Does this cause stomach problems?

Cynthia BAug 31, 2013

I've found it only causes problems (nausea) if taken with food of any substantial sort; as such, I take it directly upon waking. 20-30 minutes later food seems fine. Main issue I have noticed is a decreased appetite; not a huge one, only noticeable in a gym rat most likely! Just have it on an empty stomach and relatively early in the day and you shouldn't have any problems.

Ridge CAug 31, 2013

I've been taking 2 a day for about a year. I have never had any stomach problems, but I do take 2 probiotics daily. I've never heard of this being a side effect though.

Kelly L.Sep 1, 2013

I have been taking it for 3 years and have noticed no stomach problems. I have a history of ulcers, and it has no effect on that at all.

Madison LFeb 8, 2016purchased Jun 16, 2013

This did not cause stomach problems for me. You are supposed to take them on an empty stomach.

Becky CSep 1, 2013

Not in the least. I have taken Sam-E for years with zero stomach problems.

Trini EAug 31, 2013

I haven't had any issues and I've been taking it for quite a while.

May TSep 1, 2013

I can't say that SAMe causes stomach problems. I don't know.

Stephanie SSep 4, 2013

Hi,Not for me.

Elzbieta JSep 1, 2013

Not for us!

Mario CAug 31, 2013

Vote for the best answer above!

Does Vitamin Shoppe's sam-e contain mannitol (gives me stomach pain)? I didn't see it in the ingredients list but wanted to double check.

A shopperApr 12, 2016

The only brand, until I did my source couple years ago, that no use mannitol is this brand, it's why I choose this brand.

Jacqueline LMay 5, 2016purchased Aug 19, 2013

I am very sensitive to mannitol and have had the same problem with other brands but I have no problem with this brand.

Marli KApr 12, 2016purchased Sep 14, 2014

Vote for the best answer above!

is this free of mannitol?

A shopperMar 4, 2015

As far as I can determine there is no mannitol. There would be no reason to include a high molecule sugar in the formulation. It is not listed on the label. Usually enteric coated tablets are protein coated to disintegrate in the duodenum.

Michael YMar 4, 2015purchased Feb 28, 2013

Not that I know of - best you put your question to Vitamin Shoppe - its there product.

barbara pMar 4, 2015purchased Dec 30, 2012

That would be a question for the Vitamin Shoppe lab.........or product department.

Anne WMar 4, 2015purchased Jul 6, 2014

I'm sorry I can't answer that. Don't know.

L HMar 4, 2015purchased Mar 30, 2013

Vote for the best answer above!

Are there any issues with SaMe interacting with other vitamins or perscription meds?

paulette aMay 4, 2016

Ask your physician

Corinne LMay 4, 2016purchased Sep 4, 2013

Obviously the bottom line is to ask your physician. I was looking for any major issues with interaction before doing that.

paulette aMay 4, 2016

I had no issues.

Susan CMay 4, 2016purchased Jan 16, 2014

Vote for the best answer above!

Do you become resistant to it over time?

LARRY HFeb 8, 2016

Hi LarryIn my case, no. I did realize when it came time to address other things that were making me feel unwell, however. Hormone cream, better nutrition, apple cider vinegar, and some simple yoga/exercise.. along with few mins reading C.H.Spurgeon in the morning, work for me at the moment. The Sam-E helped when I needed it, for sure.. But I have to adjust time to time what works as my body ages. Best wishes!

Kelly WFeb 8, 2016purchased Jan 10, 2014

I have been taking it for over 3 years and have not noticed any type of resistance. I'll add that I definitely notice a change in mood etc when I have been slacking off at taking it regularly, so that's important.

Madison LFeb 8, 2016purchased Jun 16, 2013

A little, but when I stopped for a period of time...I could tell the difference. It does help. I have taken it for 2 years.

Sandra BFeb 8, 2016purchased Jun 3, 2013

No, not that I am aware. I take in for a while then I stop it for a while. I believe it helps with mood more than anything.

Martin NFeb 8, 2016purchased Mar 10, 2014

Yes, it worked for me for about 1 year.

Kathryn MFeb 8, 2016purchased Aug 31, 2013

Vote for the best answer above!

Does it work well with anxiety problems?

A shopperDec 10, 2013

SAMe is known for its use in mood elevation (the opposite of depression). I can't speak to anxiety. Try L-theanine for anxiety.

Marilynn FDec 28, 2013

Not sure--I started taking it for joint support, but I do think it has given me mood health support also.

BarbDec 10, 2013

Vote for the best answer above!

where is Sam- e manufactured?

A shopperJul 19, 2023

Best Answer: This item is manufactured in the United States.

Daniel W.staffJul 22, 2023

I have been buying the Farrow brand. I once used nature Made and it didn't work as well. Have you tried this brand?

Ruth CJul 26, 2014

Best Answer: I have taken it for over 3 years and really like it.

Madison LFeb 8, 2016purchased Jun 16, 2013

Disclaimer:

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FREE STANDARD SHIPPING on orders of $45 or more

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About The Vitamin Shoppe

Featuring a wide range of quality vitamins, minerals, and supplements at everyday low prices, every formula is verified for ingredient potency and purity—to help you become a better you.

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SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 400 MG (60 Tablets)

SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 400 MG (60 Tablets)

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Product Info

About This Product

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Warning

Supplement Facts

Other Ingredients:

Does Not Contain:

Specifications

Product Reviews
(16)

Q&A

Shipping Info

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About The Vitamin Shoppe

Inspired by Your Browsing

SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 400 MG (60 Tablets)

SAM-e - Enteric Coated - Mood, Joint, & Liver Support - 400 MG (60 Tablets)

Customers Also Viewed

Product Info

About This Product

Directions

Warning

Supplement Facts

Other Ingredients:

Does Not Contain:

Specifications

Product Reviews (16)

Q&A

Shipping Info

How to get FREE Standard Shipping:

About The Vitamin Shoppe

Inspired by Your Browsing

Product Reviews
(16)